Dabski K, Stoll H L
J Surg Oncol. 1987 Apr;34(4):217-29. doi: 10.1002/jso.2930340402.
Granulomatous reaction characterized by the formation of noncaseating accumulations of epithelioid histiocytes and multinucleated giant cells of the foreign-body type is a rare, poorly understood, and generally ignored phenomenon seen in various types of lymphoma. Its presence in cutaneous infiltrates of mycosis fungoides is equally unusual, but some favorable prognostic significance has been ascribed to it previously. In this paper, four patients with typical mycosis fungoides and granulomas demonstrated histologically in their cutaneous infiltrates are presented. All four died of disseminated disease with evidence of central nervous system involvement in three of them. These clinical histories lend no support to the notion that granulomatous mycosis fungoides is a benign variant of this lymphoma. Relevant literature is reviewed and discussed.
以非干酪样上皮样组织细胞和异物型多核巨细胞聚集形成为特征的肉芽肿反应是在各类淋巴瘤中罕见、了解甚少且普遍被忽视的现象。其出现在蕈样肉芽肿的皮肤浸润中同样不寻常，但此前已有人认为它具有一定的预后良好意义。本文报告了4例典型蕈样肉芽肿且皮肤浸润经组织学证实有肉芽肿形成的患者。所有4例均死于播散性疾病，其中3例有中枢神经系统受累证据。这些临床病史并不支持肉芽肿性蕈样肉芽肿是该淋巴瘤良性变体这一观点。对相关文献进行了回顾和讨论。
