Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China.
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, P. R. China.
Adv Healthc Mater. 2022 Jul;11(14):e2200665. doi: 10.1002/adhm.202200665. Epub 2022 Jun 3.
Enriching the application of multifunctional dendritic mesoporous organosilica (DMOS) is still challenging in anti-cancer research. Herein, manganese ions, iron ions, or cobalt ions and tetrasulfide bonds are co-incorporated into the framework of DMOS to yield multifunctional nanoparticles denoted as Mn-DMOS, Fe-DMOS, or Co-DMOS by directly doping metal ions during the synthetic process. Due to co-incorporation of metal ions and tetrasulfide bonds, these designed nanocarriers have more functions rather than only for cargo delivery. As proof of concept, the nanocomposite is established based on Mn-DMOS as an efficient nanocarrier for indocyanine green (ICG) delivery and modification with polyethylene glycol. In the tumor microenvironment, the generated hydrogen sulfide (H S) arising from the reaction between tetrasulfide bond and over-expressed glutathione (GSH) causes mitochondrial injury to reduce cellular respiration. The released Mn from the rapidly decomposed nanocomposite catalyzes the endogenous hydrogen peroxide to produce oxygen (O ). The photothermal effect from the released ICG initiated by the near-infrared light induces cancer cells apoptosis and simultaneously enhances the content of blood O at tumor sites. Therefore, due to the GSH depletion and trimodal O compensation, the photodynamic therapy efficiency of ICG has significantly improved. In brief, these designed nanocarriers will play advanced roles in cancer therapy.
多功能树枝状介孔有机硅（DMOS）的应用在抗癌研究中仍然具有挑战性。在此，锰离子、铁离子或钴离子和四硫键被共掺入 DMOS 的框架中，通过在合成过程中直接掺杂金属离子，得到多功能纳米粒子，分别表示为 Mn-DMOS、Fe-DMOS 或 Co-DMOS。由于共掺入金属离子和四硫键，这些设计的纳米载体具有更多的功能，而不仅仅是用于货物输送。作为概念验证，基于 Mn-DMOS 建立了纳米复合材料，作为吲哚菁绿（ICG）的有效纳米载体，并进行了聚乙二醇的修饰。在肿瘤微环境中，四硫键与过表达的谷胱甘肽（GSH）反应产生的硫化氢（H2S）导致线粒体损伤，从而降低细胞呼吸。从快速分解的纳米复合材料中释放的 Mn 催化内源性过氧化氢产生氧气（O2）。近红外光引发的释放的 ICG 的光热效应诱导癌细胞凋亡，并同时增加肿瘤部位的血液 O2 含量。因此，由于 GSH 耗竭和三模态 O2 补偿，ICG 的光动力治疗效率得到了显著提高。总之，这些设计的纳米载体将在癌症治疗中发挥先进作用。
