Jiangsu Key Laboratory of Drug Screening, Institute of Pharmaceutical Sciences, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
Sci Rep. 2022 May 24;12(1):8760. doi: 10.1038/s41598-022-12695-3.
7-Met, a derivative of soybean isoflavone, is a natural flavonoid compound that has been reported to have multiple signaling pathways regulation effects. This study investigated the therapeutic effects of 7-Met on mice with atopic dermatitis induced by fluorescein isothiocyanate (FITC), or oxazolone (OXZ). 7-Met ameliorated FITC or OXZ-induced atopic dermatitis symptoms by decreasing ear thickness, spleen index, mast cell activation, neutrophil infiltration and serum IgE levels in female BALB/c mice. In FITC-induced atopic dermatitis mice, 7-Met reduced Th1 cytokines production and regulated Th1/Th2 balance by downregulating the secretion of thymic stromal lymphopoietin (TSLP) via inactivation of the NF-κB pathway. In OXZ-induced atopic dermatitis, 7-Met functioned through the reduction of Th17 cytokine production. Our study showed that 7-Methoxyisoflavone alleviated atopic dermatitis by regulating multiple signaling pathways and downregulating chemokine production.
7-甲氧基异黄酮，大豆异黄酮的衍生物，是一种天然黄酮类化合物，据报道具有多种信号通路调节作用。本研究探讨了 7-甲氧基异黄酮对荧光素异硫氰酸酯（FITC）或恶唑酮（OXZ）诱导的过敏性皮炎小鼠的治疗作用。7-甲氧基异黄酮通过降低雌性 BALB/c 小鼠的耳厚、脾指数、肥大细胞活化、中性粒细胞浸润和血清 IgE 水平，改善了 FITC 或 OXZ 诱导的特应性皮炎症状。在 FITC 诱导的特应性皮炎小鼠中，7-甲氧基异黄酮通过抑制 NF-κB 通路的激活，减少 Th1 细胞因子的产生，并通过下调胸腺基质淋巴细胞生成素（TSLP）的分泌来调节 Th1/Th2 平衡。在 OXZ 诱导的特应性皮炎中，7-甲氧基异黄酮通过减少 Th17 细胞因子的产生发挥作用。我们的研究表明，7-甲氧基异黄酮通过调节多条信号通路和下调趋化因子的产生来缓解特应性皮炎。
