Yamamoto I, Tateoka Y, Watanabe K, Ho I K
Life Sci. 1987 Apr 6;40(14):1439-42. doi: 10.1016/0024-3205(87)90335-3.
N,N'-Diallylpentobarbital (DAPB) antagonized barbital (B)-induced sleep in mice and rats. DAPB [80 mg/kg, intraperitoneal (i.p.)] reduced the barbital (350 mg/kg, i.p.)-induced sleeping time to 40% of the control in mice. Twenty, 40 and 80 mg/kg, i.p. of DAPB reduced barbital-induced sleeping time when administered 60 min prior to injection of barbital. DAPB (80 mg/kg, i.p.) also shortened barbital (250 mg/kg, i.p.)-induced sleeping time to about 70% of the control in rats. The result indicates that DAPB is an antagonist against hypnotic activity of barbital.
N，N'-二烯丙基戊巴比妥（DAPB）可拮抗巴比妥（B）诱导的小鼠和大鼠睡眠。DAPB[80毫克/千克，腹腔注射（i.p.）]可将巴比妥（350毫克/千克，腹腔注射）诱导的小鼠睡眠时间缩短至对照组的40%。在注射巴比妥前60分钟腹腔注射20、40和80毫克/千克的DAPB可缩短巴比妥诱导的睡眠时间。DAPB（80毫克/千克，腹腔注射）也可将巴比妥（250毫克/千克，腹腔注射）诱导的大鼠睡眠时间缩短至对照组的约70%。结果表明，DAPB是巴比妥催眠活性的拮抗剂。
