prev. Head & Neck Surgery, Oncology Referral Center-CRO, Aviano, Pordenone, Italy.
Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Italy.
Acta Otorhinolaryngol Ital. 2022 Apr;42(2):126-139. doi: 10.14639/0392-100X-N1601.
The prognostic significance of the resection margins is still subject of conflicting opinions. The purpose of this paper is to report the results of a study on the margins in carcinoma of the oral cavity, oro-hypopharynx and larynx.
A multicentre prospective study was carried out between 2015 and 2018 with the participation of 10 Italian reference hospitals. The primary objective was to evaluate local control in patients with well-defined clinical characteristics and comprehensive histopathological information.
During the study period, 455 patients were enrolled; the minimum follow-up was 2 years. Previous treatment, grading and fresh specimen examination were identified as risk factors for local control in multivariate analysis. On the basis of these results, it seems possible to delineate "risk profiles" for different oncological outcomes.
The prognostic significance of the margins is reduced, and other risk factors emerge, which require diversified treatment and follow-up.
Multidisciplinary treatment with adjuvant therapy, if indicated, reduces the prognostic importance of margins. Collaboration with a pathologist is an additional favourable prognostic factor and quality indicator.
An appendix with literature review is present in the online version.
切除边缘的预后意义仍存在争议。本文旨在报告一项关于口腔、口咽和喉癌边缘的研究结果。
2015 年至 2018 年期间，10 家意大利参考医院参与了一项多中心前瞻性研究。主要目的是评估具有明确临床特征和全面组织病理学信息的患者的局部控制情况。
研究期间共纳入 455 例患者；最小随访时间为 2 年。多变量分析显示，先前的治疗、分级和新鲜标本检查是局部控制的危险因素。基于这些结果，似乎可以为不同的肿瘤学结果划定“风险概况”。
边缘的预后意义降低，出现了其他危险因素，需要进行多样化的治疗和随访。
有辅助治疗的多学科治疗降低了边缘的预后重要性。与病理学家的合作是另一个有利的预后因素和质量指标。
在线版本中有文献综述附录。
