Gao Xuebo, Chang Rong, Rao Junxin, Hao Danyang, Zhang Zhuxia, Zhou Cong-Ying, Guo Zhen
College of Materials Science and Engineering, Key Laboratory of Interface Science and Engineering in Advanced Materials, Ministry of Education, Taiyuan University of Technology, Taiyuan, Shanxi 030024, People's Republic of China.
College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, People's Republic of China.
J Org Chem. 2022 Jun 17;87(12):8198-8202. doi: 10.1021/acs.joc.2c00413. Epub 2022 May 25.
Herein, we report a halogen-bonding-based electron donor-acceptor (EDA) complex-promoted photoreaction for the synthesis of C2-malonylated indoles. The protocol provides access to a broad range of functionalized indoles in good yields through the coupling reaction of indoles with diethyl bromomalonate under visible-light irradiation without the need for any transition-metal catalyst or photocatalyst.
