利用氧化钙原位化学衰减药物活性化合物：影响因素、机理建模和水传播微生物病原体的协同灭活。
In-situ chemical attenuation of pharmaceutically active compounds using CaO: Influencing factors, mechanistic modeling, and cooperative inactivation of water-borne microbial pathogens.
机构信息
Key Laboratory of Organic Compound Pollution Control Engineering (MOE), School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China; Department of Civil & Environmental Engineering, University of Alberta, Edmonton, Alberta, T6G 1H9, Canada; Shunde Graduate School of University of Science and Technology Beijing, Foshan City, Guangdong, 528399, China.
Key Laboratory of Organic Compound Pollution Control Engineering (MOE), School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
出版信息
Environ Res. 2022 Sep;212(Pt D):113531. doi: 10.1016/j.envres.2022.113531. Epub 2022 May 22.
Water polluted by pharmaceutically active compounds (PhACs) and water-borne pathogens urgently need to develop eco-friendly and advanced water treatment techniques. This paper evaluates the potential of using calcium peroxide (CaO), a safe and biocompatible oxidant both PhACs (thiamphenicol, florfenicol, carbamazepine, phenobarbital, and primidone) and pathogens (Escherichia coli, Staphylococcus aureus) in water. This paper evaluates the potential of using calcium peroxide (CaO) as a safe and biocompatible oxidant to remove both PhACs (thiamphenicol, florfenicol, carbamazepine, phenobarbital, and primidone) and pathogens (Escherichia coli, Staphylococcus aureus) in water. The increased CaO dosage increased efficiencies of PhACs attenuation and pathogens inactivation, and both exhibited pseudo-first-order degradation kinetics (R > 0.90). PhACs attenuation were mainly via oxidization (HO, •OH/O, and O) and alkaline hydrolysis (OH) from CaO. Moreover, concentrations of these reactive species and their contributions to PhACs attenuation were quantified, and mechanistic model was established and validated. Besides, possible transformation pathways of target PhACs except primidone were proposed. As for pathogen indicators, the suitable inactivation dosage of CaO was 0.1 g L. The oxidability (18-64%) and alkalinity (82-36%) generated from CaO played vital roles in pathogen inactivation. In addition, CaO at 0.01-0.1 g L can be applied in remediation of SW contaminated by PhACs and pathogenic bacteria, which can degrade target PhACs with efficiencies of 21-100% under 0.01 g L CaO, and inactivate 100% of test bacteria under 0.1 g L CaO. In short, capability of CaO to remove target PhACs and microbial pathogens reveals its potential to be used as a representative technology for the advanced treatment of waters contaminated by organic compounds and microbial pathogens.
受药物活性化合物（PhACs）和水传播病原体污染的水迫切需要开发环保和先进的水处理技术。本文评估了使用过氧化钙（CaO）的潜力，过氧化钙是一种安全且生物相容的氧化剂，可去除水中的 PhACs（噻苯达唑、氟苯尼考、卡马西平、苯巴比妥和扑米酮）和病原体（大肠杆菌、金黄色葡萄球菌）。本文评估了使用过氧化钙（CaO）作为安全且生物相容的氧化剂的潜力，以去除水中的 PhACs（噻苯达唑、氟苯尼考、卡马西平、苯巴比妥和扑米酮）和病原体（大肠杆菌、金黄色葡萄球菌）。增加的 CaO 剂量提高了 PhACs 衰减和病原体失活的效率，两者均表现出伪一级降解动力学（R>0.90）。PhACs 的衰减主要通过 CaO 的氧化（HO、•OH/O 和 O）和碱性水解（OH）实现。此外，还定量了这些活性物质的浓度及其对 PhACs 衰减的贡献，并建立和验证了机理模型。此外，还提出了除扑米酮以外的目标 PhACs 的可能转化途径。对于病原体指标，CaO 的合适灭活剂量为 0.1 g L。CaO 产生的氧化性（18-64%）和碱性（82-36%）在病原体失活中起着重要作用。此外，0.01-0.1 g L 的 CaO 可用于修复受 PhACs 和病原菌污染的 SW，在 0.01 g L CaO 下，可使目标 PhACs 的降解效率达到 21-100%，在 0.1 g L CaO 下，可使测试细菌全部失活。总之，CaO 去除目标 PhACs 和微生物病原体的能力表明其有潜力用作去除有机化合物和微生物病原体污染水的高级处理技术的代表技术。
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