Department of Neurosurgery, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, 350009, China.
Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, 350025, China.
Eur J Med Res. 2022 May 25;27(1):72. doi: 10.1186/s40001-022-00700-4.
To assess the factors influencing the development of diabetes insipidus after transsphenoidal surgery for pituitary adenomas.
We retrospectively analyzed the clinical data of patients with pituitary adenoma who underwent transsphenoidal surgery. The pituitary gland was assessed using a 3.0 T magnetic resonance imaging, and the predictors of postoperative diabetes insipidus were determined through univariate and multivariate analyses.
A total of 212 eligible patients with pituitary adenomas were included; 82 (38.7%) cases developed postoperative diabetes insipidus while 130 cases (61.3%) did not. Diabetes insipidus was transient in 80 (37.7%) patients and permanent in 2 (0.9%) patients. The results of logistic regression analyses showed that the change in cephalocaudal tumor cavity diameter after transsphenoidal surgery was associated with the occurrence of postoperative diabetes insipidus.
Change in cephalocaudal tumor cavity diameter after transsphenoidal surgery may play an important role in predicting diabetes insipidus onset in patients with a pituitary adenoma.
评估经蝶窦手术治疗垂体腺瘤后发生尿崩症的影响因素。
我们回顾性分析了经蝶窦手术治疗的垂体腺瘤患者的临床资料。使用 3.0T 磁共振成像评估垂体，通过单因素和多因素分析确定术后尿崩症的预测因子。
共纳入 212 例符合条件的垂体腺瘤患者；82 例（38.7%）发生术后尿崩症，130 例（61.3%）未发生。80 例（37.7%）为暂时性尿崩症，2 例（0.9%）为永久性尿崩症。Logistic 回归分析结果显示，经蝶窦手术后颅尾肿瘤腔直径的变化与术后尿崩症的发生有关。
经蝶窦手术后颅尾肿瘤腔直径的变化可能在预测垂体腺瘤患者尿崩症的发生中起重要作用。
