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早期诊断可挽救生命:巴基斯坦两名糖尿病酮症酸中毒患儿的毛霉菌病

Early suspicion can save lives; mucormycosis in two children with diabetic ketoacidosis in Pakistan.

作者信息

Shahid Ayesha, Fatima Batool, Khan Yasir Naqi, Ibrahim Mohsina Noor, Raza Jamal

机构信息

Final Year MBBS Student, Jinnah Sindh Medical University, Karachi, Pakistan.

Department of Paediatrics, National Institute of Child Health, Karachi.

出版信息

J Pak Med Assoc. 2022 Apr;72(4):790-792. doi: 10.47391/JPMA.1659.

Abstract

Mucormycosis is a cause of fulminant necrotising fungal infection in children with underlying immunocompromising conditions. Rhino-orbito-cerebral infection is its most common form in the paediatric group with uncontrolled diabetes mellitus or diabetic ketoacidosis. The initial presentation can mimic a bacterial infection; thus a high index of suspicion is needed for timely intervention to reduce morbidity and mortality. We have presented a case of rhino-orbito-cerebral mucormycosis (ROCM) in two patients with diabetic ketoacidosis for the first time from Pakistan. Both the patients couldnot survive due to extensive disease on late presentation.

摘要

毛霉菌病是患有潜在免疫功能低下疾病儿童暴发性坏死性真菌感染的一个病因。鼻眶脑型感染是患有未控制的糖尿病或糖尿病酮症酸中毒的儿科患者中最常见的形式。其初始表现可能类似细菌感染;因此,需要高度怀疑以进行及时干预,从而降低发病率和死亡率。我们首次从巴基斯坦报道了两例患有糖尿病酮症酸中毒的鼻眶脑型毛霉菌病(ROCM)病例。两名患者均因就诊晚且病情广泛而未能存活。

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