Yang Yunlong, Li Yan, Lin Qiuning, Bao Chunyan, Zhu Linyong
Key Laboratory for Advanced Materials, Institute of Fine Chemicals, East China University of Science and Technology, 130# Meilong Road, Shanghai 200237, China.
ACS Macro Lett. 2016 Mar 15;5(3):301-305. doi: 10.1021/acsmacrolett.5b00870. Epub 2016 Feb 11.
In situ forming redox responsive nanoparticles have been developed based on amphiphilic copolymers-phototriggered disulfide-cross-link macromolecules (PDCM). Upon 405 nm light irradiation, the macrocyclic thiol caged coumarin phototrigger in PDCM can release free thiols, and these free thiols subsequently realize in situ disulfide cross-link via reacting with a pyridyl disulfide group inside the PDCM assembled nanoparticles. The phototriggered disulfide-cross-link strategy can be conducted rapidly, conveniently, and cleanly without adding any cross-linkers or catalysts. Via changing irradiation condition, nanoparticles with different cross-link densities can be formed. These nanoparticles can encapsulate hydrophobic guest molecules with good stability and achieve redox-triggered release under GSH reduction. Intracellular experiments show that these nanoparticles can be used as promising drug carriers.
基于两亲性共聚物 - 光触发二硫键交联大分子（PDCM）开发了原位形成的氧化还原响应性纳米颗粒。在405 nm光照射下，PDCM中的大环硫醇笼状香豆素光触发剂可释放游离硫醇，这些游离硫醇随后通过与PDCM组装纳米颗粒内部的吡啶二硫基团反应实现原位二硫键交联。光触发二硫键交联策略可以快速、方便且无污染地进行，无需添加任何交联剂或催化剂。通过改变照射条件，可以形成具有不同交联密度的纳米颗粒。这些纳米颗粒可以稳定地包裹疏水性客体分子，并在谷胱甘肽还原作用下实现氧化还原触发释放。细胞内实验表明，这些纳米颗粒有望用作药物载体。
