Hou Sheng-Shu, Hsu Yu-Yun, Lin Jia-Hsien, Jan Jeng-Shiung
Department of Chemical Engineering, National Cheng Kung University, Tainan 701, Taiwan.
ACS Macro Lett. 2016 Nov 15;5(11):1201-1205. doi: 10.1021/acsmacrolett.6b00716. Epub 2016 Oct 13.
We report alkyl-poly(l-threonine)/cyclodextrin (alkyl-PLT/CD) supramolecular hydrogels with different molecular assemblies. Their properties are determined by the interplay between host-guest chemistry and hydrogen-bonding interactions. The gelation process was mainly dictated by the formation of alkyl chain/CD inclusion complex and PLT chain conformation. The dodecyl-PLT/α-CD hydrogel exhibited laminar packing due to the sheet-to-coil conformational change upon forming inclusion complex. The hexadecyl-PLT/β-CD hydrogel exhibited ribbon-like assemblies instead, because the peptide adopted mainly sheet conformation. The gel-to-sol transition occurred upon increasing temperature because of the decrease in hydrogen-bonding interactions and partly conformational change.
我们报道了具有不同分子组装结构的烷基-聚（L-苏氨酸）/环糊精（alkyl-PLT/CD）超分子水凝胶。它们的性质由主客体化学和氢键相互作用之间的相互作用决定。凝胶化过程主要由烷基链/CD包合物的形成和PLT链构象决定。十二烷基-PLT/α-CD水凝胶由于形成包合物时发生片层到卷曲的构象变化而呈现层状堆积。相反，十六烷基-PLT/β-CD水凝胶呈现带状组装，因为肽主要采用片层构象。由于氢键相互作用的减少和部分构象变化，温度升高时会发生凝胶-溶胶转变。
