Su Teng, Liu Yi, He Hongjian, Li Jia, Lv Yanan, Zhang Lili, Sun Yao, Hu Chunpu
Department of Chemistry, Advanced Research Institute, Tongji University, Shanghai 200092, China.
Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695-7115, United States.
ACS Macro Lett. 2016 Nov 15;5(11):1217-1221. doi: 10.1021/acsmacrolett.6b00702. Epub 2016 Oct 18.
Inspired by the delicate architecture of hyaline articular cartilage, we report on a biomimetic polymer hydrogel that incorporates strong intermolecular hydrogen bonding between urethane-urethane linkages as well as urethane-ester linkages. The resultant hydrogel, containing ≈75% water, can endure a compressive stress up to 56 MPa with a strain of 98%, and exhibit tunable compressive modulus (0.19-1.38 MPa), as well as toughness (3629-28290 J m) within a wide range. The tensile strength and elastic modulus reach as high as 0.56 and 5.5 MPa, respectively. The high stiffness and toughness enable the gel to withstand cyclic compressive loadings without fracturing. Moreover, our hydrogel mimics the extracellular matrices of cartilage and bone tissues and provides biochemical and physical cues that support the three-dimensional proliferation of chondrocytes and osteogenic differentiation of preosteoblasts.
受透明关节软骨精细结构的启发，我们报道了一种仿生聚合物水凝胶，它在聚氨酯 - 聚氨酯键以及聚氨酯 - 酯键之间形成了强大的分子间氢键。所得水凝胶含水量约为75%，能承受高达56 MPa的压缩应力，应变达98%，并在很宽范围内展现出可调的压缩模量（0.19 - 1.38 MPa）以及韧性（3629 - 28290 J/m）。拉伸强度和弹性模量分别高达0.56和5.5 MPa。高刚度和韧性使凝胶能够承受循环压缩载荷而不破裂。此外，我们的水凝胶模仿软骨和骨组织的细胞外基质，并提供支持软骨细胞三维增殖和成骨前体细胞成骨分化的生化和物理信号。
