CYP17A1、CYP19A1和性激素结合球蛋白基因多态性与多囊卵巢综合征易感性的关联：一项系统评价和荟萃分析
The Association of CYP17A1, CYP19A1, and SHBG Gene Polymorphisms in Polycystic Ovary Syndrome Susceptibility: A Systematic Review and Meta-Analysis.
作者信息
Xing Chuan, Zhao Han, Zhang Jiaqi, He Bing
机构信息
The First Endocrine Department of Shengjing Hospital of China Medical University, Shenyang, China.
出版信息
Front Physiol. 2022 May 9;13:741285. doi: 10.3389/fphys.2022.741285. eCollection 2022.
To elucidate the relationship between CYP17A1/CYP19A1/SHBG gene polymorphisms and PCOS susceptibility. We searched multiple databases from inception to December 2020 and meta analysis was conducted to elucidate the relationship between gene polymorphisms and PCOS risk. 26 studies were included, comprising 4860 PCOS and 4043 controls. CYP17A1 rs743572 polymorphisms were found to be negatively associated with PCOS risk under dominant model ( = 0.017, OR = 0.83, 95%CI 0.72-0.97, = 74.80%, = 0.000) in the general population while neither CYP19A1 rs2414096 polymorphisms ( = 0.578, OR = 0.87, 95%CI 0.54-1.41, = 95.90%, = 0.000) nor SHBG rs6529 polymorphisms ( = 0.752, OR = 0.99, 95%CI 0.94-1.05, = 60.90%, = 0.012) was associated with PCOS susceptibility under dominant model in the general population. CYP17A1 rs7435721 polymorphisms might be protective factors against PCOS in general populations. : https://www.crd.york.ac.uk/prospero/#myprospero, identifier CRD4202122640.
为阐明CYP17A1/CYP19A1/SHBG基因多态性与多囊卵巢综合征（PCOS）易感性之间的关系。我们检索了从数据库建立至2020年12月的多个数据库，并进行荟萃分析以阐明基因多态性与PCOS风险之间的关系。纳入了26项研究，包括4860例PCOS患者和4043例对照。在显性模型下，发现CYP17A1 rs743572多态性与一般人群中的PCOS风险呈负相关（P = 0.017，OR = 0.83，95%CI 0.72 - 0.97，I² = 74.80%，P = 0.000），而在显性模型下，CYP19A1 rs2414096多态性（P = 0.578，OR = 0.87，95%CI 0.54 - 1.41，I² = 95.90%，P = 0.000）和SHBG rs6529多态性（P = 0.752，OR = 0.99，95%CI 0.94 - 1.05，I² = 60.90%，P = 0.012）均与一般人群中的PCOS易感性无关。CYP17A1 rs7435721多态性可能是一般人群中PCOS的保护因素。：https://www.crd.york.ac.uk/prospero/#myprospero，标识符CRD4202122640。
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