Li Jiefang, Wu Dan, Li Xi
Traditional Chinese Medicine Department, The Fourth Hospital of Changsha, Changsha, China.
Evid Based Complement Alternat Med. 2022 May 16;2022:7479416. doi: 10.1155/2022/7479416. eCollection 2022.
The purpose of the study is to investigate the clinical efficacy and long-term prognosis of acupuncture (AP) combined with atorvastatin (ATO) in treating senile essential hypertension (EH) complicated with carotid atherosclerosis (CA).
108 elderly EH patients with CA admitted to our hospital between January 2018 and September 2018 were enrolled into the study, consisting of 67 patients who received treatment of AP with ATO (AP + ATO group) and 41 patients who received treatment of ATO alone (ATO group). Comparative outcomes included clinical efficacy, blood pressure (BP), the levels of blood lipids and inflammatory factors, carotid intima-media thickness (IMT), the number of unstable carotid intima plaques, the carotid plaque area, and the incidence of adverse reactions. All patients were followed up for 3 years to evaluate their quality of life and the recurrence rate of CA.
The AP + ATO group presented a higher efficacy, a declined BP, and lower posttreatment levels of blood lipids and inflammatory factors than the ATO group ( < 0.05). Reductions were observed in IMT, number of plaques, and plaque area in both groups after treatment, with more significant improvements in the AP + ATO group ( < 0.05). No difference was observed in the incidence of adverse reactions between two groups after treatment ( > 0.05). The follow-up analysis demonstrated a higher SF-36 score and a lower recurrence rate of CA in the AP + ATO group than the ATO group ( < 0.05).
The findings suggested that, for elderly EH patients with CA, treatment of AP with ATO offers better clinical efficacy and safety, which not only can decline the BP, but also can reduce blood lipids and plaque formation, and improve quality of life.
本研究旨在探讨针刺（AP）联合阿托伐他汀（ATO）治疗老年原发性高血压（EH）合并颈动脉粥样硬化（CA）的临床疗效及长期预后。
选取2018年1月至2018年9月我院收治的108例老年EH合并CA患者，其中67例接受AP联合ATO治疗（AP + ATO组），41例仅接受ATO治疗（ATO组）。比较的结果包括临床疗效、血压（BP）、血脂和炎症因子水平、颈动脉内膜中层厚度（IMT）、不稳定颈动脉内膜斑块数量、颈动脉斑块面积及不良反应发生率。所有患者随访3年，评估其生活质量及CA复发率。
AP + ATO组的疗效更高，血压下降，治疗后血脂和炎症因子水平低于ATO组（<0.05）。两组治疗后IMT、斑块数量和斑块面积均降低，AP + ATO组改善更显著（<0.05）。治疗后两组不良反应发生率无差异（>0.05）。随访分析显示，AP + ATO组的SF - 36评分高于ATO组，CA复发率低于ATO组（<0.05）。
研究结果表明，对于老年EH合并CA患者，AP联合ATO治疗具有更好的临床疗效和安全性，不仅可降低血压，还可降低血脂、减少斑块形成并改善生活质量。
