青少年成熟型糖尿病3型与卵巢早衰：巧合还是因果关系：一例病例报告及文献综述
Maturity-onset diabetes of the young type 3 and premature ovarian insufficiency: chance or causality: a case report and literature review.
作者信息
Alvarez Mauricio, Rincon Oswaldo, Alvarado Alejandra, Puentes Francisco
机构信息
Sanitas EPS, Hospital Militar Central, Bogotá, Colombia.
Sanitas EPS, Bogotá, Colombia.
出版信息
Endocrinol Diabetes Metab Case Rep. 2022 May 1;2022. doi: 10.1530/EDM-21-0166.
SUMMARY
We present the case of a 23-year-old patient with maturity-onset diabetes of the young type 3 (MODY 3) and premature ovarian insufficiency (POI). There is no known correlation between MODY 3 and POI, although POI can impair glucose metabolism, and MODY can cause microvascular complications such as POI. We did not find literature describing a correlation between these two pathologies nor did we find similar cases described in the literature.
LEARNING POINTS
Maturity-onset diabetes of the young type 3 (MODY 3) is an infrequent cause of diabetes that should be considered in young patients with atypical presentation of type 1 or type 2 diabetes. MODY 3 can be associated with microvascular complications of diabetes, which is why it is important to diagnose as early as possible. Impairment of glucose metabolism has been demonstrated in patients with premature ovarian insufficiency and menopause.
摘要
我们报告了一例23岁的年轻成年发病型糖尿病3型（MODY 3）合并卵巢早衰（POI）的患者。尽管POI可损害糖代谢，而MODY可导致如POI等微血管并发症，但目前尚无已知的MODY 3与POI之间的关联。我们未找到描述这两种病理之间关联的文献，也未在文献中发现类似病例的描述。
学习要点
年轻成年发病型糖尿病3型（MODY 3）是糖尿病的一种罕见病因，在1型或2型糖尿病表现不典型的年轻患者中应予以考虑。MODY 3可与糖尿病的微血管并发症相关，这就是尽早诊断很重要的原因。卵巢早衰和绝经患者已证实存在糖代谢受损。
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