Pedersen Julie Elbaek, Strandberg-Larsen Katrine, Andersson Michael, Hansen Johnni
Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.
Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Am J Ind Med. 2022 Aug;65(8):660-668. doi: 10.1002/ajim.23397. Epub 2022 May 26.
Organic solvents have been suggested to increase the risk of breast cancer although the epidemiologic evidence is limited. This study explored the association between organic solvents and breast cancer.
This nested population-based case-control study comprised 845 women with primary breast cancer initially identified in the Danish Cancer Registry between 2000 and 2003, and 1500 controls matched on year of birth who were randomly selected from the Danish Civil Registration System. Information on occupational exposure to organic solvents, and specifically ethanol, as well as risk factors for breast cancer was collected through structured interviews.
For organic solvents, an increased risk was indicated for ever-exposure (odds ratio = 3.20, 95% confidence interval: 2.27-4.52), however, no noteworthy risk patterns were detected when exploring duration of exposure and cumulative exposure. Ever-exposure to organic solvents was associated with an increased risk of estrogen receptor negative and positive tumors as well as pre- and postmenopausal breast cancer. No associations were detected between occupational exposure to ethanol and breast cancer.
This study indicates a positive association between organic solvents and breast cancer.
尽管流行病学证据有限，但有机溶剂已被认为会增加患乳腺癌的风险。本研究探讨了有机溶剂与乳腺癌之间的关联。
这项基于人群的巢式病例对照研究包括845名2000年至2003年间最初在丹麦癌症登记处确诊的原发性乳腺癌女性患者，以及1500名从丹麦民事登记系统中随机选取的、按出生年份匹配的对照。通过结构化访谈收集了职业接触有机溶剂特别是乙醇的信息以及乳腺癌的危险因素。
对于有机溶剂，曾经接触者的风险有所增加（比值比=3.20，95%置信区间：2.27 - 4.52），然而，在探究接触时长和累积接触情况时未发现显著的风险模式。曾经接触有机溶剂与雌激素受体阴性和阳性肿瘤以及绝经前和绝经后乳腺癌的风险增加相关。未发现职业接触乙醇与乳腺癌之间存在关联。
本研究表明有机溶剂与乳腺癌之间存在正相关。
