Kemona H, Wysocka J, Prokopowicz J, Kiluk S
Neoplasma. 1987;34(1):107-13.
In 41 patients with Hodgkin's disease nitroblue tetrazolium (NBT) dye reduction with resting and stimulated granulocytes, before, in the course and after chemotherapy was examined. Twofold decrease of the capability of NBT reduction test with stimulated granulocytes was found, whereas with resting granulocytes only slight diminution was noted. Chemotherapy did not improve the tested parameters. No relationship was observed between the stage of disease and the presence of systemic symptoms and the NBT dye reduction. It can be assumed that granulocytes from patients with Hodgkin's disease are resistant to stimulation. The observations suggest that NBT test may be useful for evaluation of the function of granulocytes and to some extent for monitoring of the chemotherapy.
对41例霍奇金病患者，检测了化疗前、化疗期间及化疗后静息和刺激状态下粒细胞的硝基蓝四氮唑（NBT）染料还原能力。发现刺激状态下粒细胞的NBT还原试验能力下降了两倍，而静息粒细胞仅略有降低。化疗并未改善所检测的参数。未观察到疾病分期、全身症状的存在与NBT染料还原之间的关系。可以推测，霍奇金病患者的粒细胞对刺激有抗性。这些观察结果表明，NBT试验可能有助于评估粒细胞功能，并在一定程度上用于监测化疗。
