Desatnik P, Alm P, Elisson O, Olsson H
Neoplasma. 1987;34(1):115-8.
In two separate groups of lung cancer patients, the cranio-caudal site of tumor presentation was related to smoking habits. Group I consisted of 47 inoperable lung cancer patients. In this group apical lung tumor presentation was significantly more common in nonsmokers than in smokers (p less than 0.04). The proportion of women and patients with adenocarcinoma was higher for nonsmokers (p less than 0.01 and p less than 0.01, respectively). In order to validate these findings the site of tumor presentation in relation to smoking habits was studied for a separate group of 369 lung cancer patients. All these patients (group II) had operable tumors. In general, these patients were younger and came from more urban areas than the patients in group I. In group II, upper lobe tumor presentation was not more common among nonsmokers compared with tumor presentation in smokers (p greater than 0.05). However, there were more patients with adenocarcinomas and women among nonsmokers (p less than 0.0001 and p less than 0.0001, respectively). The findings indicate that either the tumor site of presentation in operable and in inoperable lung cancer patients has different epidemiological characteristics, or that, due to chance, a difference in the groups has been observed. However, consistently in the two groups, women with adenocarcinomas who were smokers were younger than other women with adenocarcinomas.
在两组不同的肺癌患者中，肿瘤出现的头尾部位与吸烟习惯有关。第一组由47例无法手术的肺癌患者组成。在这组中，肺尖部肿瘤在不吸烟者中比吸烟者中显著更常见（p<0.04）。不吸烟者中女性和腺癌患者的比例更高（分别为p<0.01和p<0.01）。为了验证这些发现，对另一组369例肺癌患者的肿瘤出现部位与吸烟习惯的关系进行了研究。所有这些患者（第二组）都有可手术的肿瘤。一般来说，这些患者比第一组患者更年轻，来自城市地区更多。在第二组中，与吸烟者的肿瘤出现情况相比，不吸烟者中上叶肿瘤出现并不更常见（p>0.05）。然而，不吸烟者中腺癌患者和女性更多（分别为p<0.0001和p<0.0001）。这些发现表明，要么可手术和不可手术肺癌患者的肿瘤出现部位具有不同的流行病学特征，要么是由于偶然因素，在两组中观察到了差异。然而，在两组中始终一致的是，吸烟的腺癌女性患者比其他腺癌女性患者更年轻。
