Department of Obstetrics and Gynaecology, Women and Children's Health Research Institute, University of Alberta, Edmonton, Canada.
Department of Physiology, University of Alberta, Edmonton, Canada.
J Dev Orig Health Dis. 2022 Dec;13(6):794-799. doi: 10.1017/S2040174422000216. Epub 2022 May 26.
Prenatal hypoxia is a common complication of pregnancy and is associated with detrimental health outcomes, such as impaired cardiac and vascular function, in adult offspring. Exposure to prenatal hypoxia reportedly impacts the reproductive system of female offspring. Whether exposure to prenatal hypoxia influences pregnancy adaptations and outcomes in these female offspring is unknown. We hypothesised that prenatal hypoxia impairs uterine artery adaptations in pregnancies of the adult offspring. Pregnancy outcomes and uterine artery function were assessed in 14-16 weeks old non-pregnant and late pregnant (gestational day 20; term = 22 days) adult female offspring born to rats exposed to prenatal normoxia (21% oxygen) or hypoxia (11% oxygen, between days 15-21 of gestation). Compared with normoxia controls, prenatal hypoxia was associated with pregnant adult offspring having reduced placental weights in their litters, and uterine artery circumferential stress that increased with pregnancy. Overall, prenatal hypoxia adversely, albeit mildly, compromised pregnancies of adult offspring.
产前缺氧是妊娠的常见并发症，与成年后代心脏和血管功能受损等不良健康结果有关。据报道，产前缺氧会影响雌性后代的生殖系统。暴露于产前缺氧是否会影响这些雌性后代的妊娠适应性和结果尚不清楚。我们假设产前缺氧会损害成年后代子宫动脉的适应性。在怀孕 14-16 周的非怀孕和晚期怀孕（妊娠第 20 天；足月= 22 天）的成年雌性后代中，评估了出生于在妊娠第 15-21 天暴露于产前常氧（21%氧气）或低氧（11%氧气）的大鼠的妊娠结局和子宫动脉功能。与常氧对照组相比，产前低氧与怀孕成年后代的胎盘中的胎盘重量减轻有关，并且随着妊娠的进行，子宫动脉周向应力增加。总的来说，产前低氧虽然程度较轻，但对成年后代的妊娠不利。
