Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China.
Int J Mol Med. 2022 Jul;50(1). doi: 10.3892/ijmm.2022.5150. Epub 2022 May 26.
As a major proton‑gated cation channel, acid‑sensitive ion channels (ASICs) can perceive large extracellular pH changes. ASICs play an important role in the occurrence and development of diseases of various organs and tissues including in the heart, brain, and gastrointestinal tract, as well as in tumor proliferation, invasion, and metastasis in acidosis and regulation of an acidic microenvironment. The permeability of ASICs to sodium and calcium ions is the basis of their physiological and pathological roles in the body. This review summarizes the physiological and pathological mechanisms of ASICs in digestive system diseases, which plays an important role in the early diagnosis, treatment, and prognosis of digestive system diseases related to ASIC expression.
作为一种主要的质子门控阳离子通道，酸敏感离子通道（ASICs）可以感知到细胞外液 pH 值的巨大变化。ASICs 在各种器官和组织的疾病发生和发展中发挥着重要作用，包括心脏、大脑和胃肠道，以及在酸中毒和酸性微环境调节中的肿瘤增殖、侵袭和转移。ASICs 对钠离子和钙离子的通透性是其在体内生理和病理作用的基础。本综述总结了 ASICs 在消化系统疾病中的生理和病理机制，这对与 ASIC 表达相关的消化系统疾病的早期诊断、治疗和预后具有重要意义。
