Ademhan Tural Dilber, Yalcin Ebru, Emiralioglu Nagehan, Ozsezen Beste, Alp Alpaslan, Sunman Birce, Gozmen Onur, Dogru Deniz, Ozcelik Ugur, Kiper Nural
Department of Pediatric Pulmonology, School of Medicine, Hacettepe University, Ihsan Dogramaci Children's Hospital, Ankara, Turkey.
Department of Medical Microbiology, School of Medicine, Hacettepe University, Ankara, Turkey.
Pediatr Int. 2022 Jan;64(1):e15102. doi: 10.1111/ped.15102.
We aimed to compare the clinical findings of human bocavirus (HBoV) and human metapneumovirus (HMPV) infections, and to analyze the effects of coinfections on clinical features and disease severity in children with HBoV and HMPV infections.
Data were collected from 125 children with lower respiratory tract infections due to HBoV or HMPV, detected from nasal swap by real-time polymerase chain reaction (PCR) during the period from January, 2013 to December, 2017. In total, there were 101 HBoV (group 1) and 23 HMPV (group 2) infections in our data. The patients were further divided into four subgroups according to the coinfection status: HoBV only (subgroup 1, n = 41), HMPV only (subgroup 2, n = 19), HBoV and coinfection with other respiratory viruses (subgroup 3, n = 60), and HMPV and coinfection with other respiratory viruses (subgroup 4, n = 4).
The majority (88.8%) of the patients were aged 5 years or younger. Coinfections with other respiratory viruses were significantly more common in group 1 (P = 0.001). Among patients who had nosocomial pneumonia, patients with HBoV infections had significantly longer mean length of hospital stay (LOS) than those with HMPV infections (P = 0.032). The hospitalization and antibiotic requirements were significantly higher in subgroup 1 than subgroup 3 (P = 0.005, 0.039, resp.) According to the logistic regression analyses, the LOS increased by 21.7 times with HBoV infections (P = 0.006).
Human bocavirus and HMPV infections are serious pathogens mostly seen in children and usually requiring hospitalization regardless of co-infection status. The HBoV infections caused longer LOS than the HMPV infections in patients with nosocomial infections.
我们旨在比较人博卡病毒（HBoV）和人偏肺病毒（HMPV）感染的临床特征，并分析合并感染对HBoV和HMPV感染儿童临床特征及疾病严重程度的影响。
收集了2013年1月至2017年12月期间，通过实时聚合酶链反应（PCR）从鼻拭子中检测出的125例因HBoV或HMPV引起的下呼吸道感染儿童的数据。我们的数据中共有101例HBoV感染（第1组）和23例HMPV感染（第2组）。根据合并感染情况，将患者进一步分为四个亚组：仅HBoV感染（亚组1，n = 41），仅HMPV感染（亚组2，n = 19），HBoV与其他呼吸道病毒合并感染（亚组3，n = 60），以及HMPV与其他呼吸道病毒合并感染（亚组4，n = 4）。
大多数（88.8%）患者年龄在5岁及以下。第1组中与其他呼吸道病毒的合并感染明显更常见（P = 0.001）。在患有医院获得性肺炎的患者中，HBoV感染患者的平均住院时间（LOS）明显长于HMPV感染患者（P = 0.032）。亚组1的住院率和抗生素使用需求明显高于亚组3（分别为P = 0.005，0.039）。根据逻辑回归分析，HBoV感染使住院时间增加了21.7倍（P = 0.006）。
人博卡病毒和HMPV感染是主要见于儿童的严重病原体，无论合并感染情况如何通常都需要住院治疗。在医院获得性感染患者中，HBoV感染导致的住院时间比HMPV感染更长。
