患有多种慢性病患者的勃起功能障碍：一项横断面研究。

Erectile Dysfunction in Patients with Multiple Chronic Conditions: A Cross- Sectional Study.

作者信息

Lisco Giuseppe, Bartolomeo Nicola, Ramunni Maria Isabella, De Tullio Anna, Carbone Matteo Domenico, Guastamcchia Edoardo, De Pergola Giovanni, Triggiani Vincenzo, Giagulli Vito Angelo

机构信息

Section of Internal Medicine, Geriatrics, Endocrinology, and Rare Disease, Interdisciplinary Department of Medicine, University of Bari, School of Medicine, Policlinico, Bari, Italy.

Department of Biomedical Science and Human Oncology, University of Bari, Bari, Italy.

出版信息

Endocr Metab Immune Disord Drug Targets. 2023;23(3):396-404. doi: 10.2174/1871530322666220523130212.

DOI:10.2174/1871530322666220523130212

PMID:35616670

Abstract

BACKGROUND

The prevalence of erectile dysfunction (ED) rises with the number and severity of chronic diseases.

AIMS

This cross-sectional study assessed the frequency and severity of ED in patients with multiple chronic conditions.

METHODS

The 5-item International Index of Erectile Function questionnaire (IIEF-5) was used to diagnose and classify ED. The Charlson Comorbidity Index (CCI) was used to assess the burden of chronic comorbidity. The primary outcome was to assess the ED frequency according to CCI severity. The secondary outcomes included the assessment of the correlation between 1) IIEF-5 and total testosterone (TT), 2) CCI and TT, and 3) IIEF-5 and CCI. Lastly, the CCI and modified CCI (mCCI) performances were compared with each other.

RESULTS

The overall frequency of ED increased along with the CCI score severity: 45% for CCI=0; 95% for CCI=1; 91% for CCI=2; 99% for CCI≥3 (p<.0001). CCI correlated negatively with TT levels and IIEF-5 score (r=-0.34 and -0.44; p<.0001). Compared to the CCI, a novel proposed mCCI performs well.

DISCUSSION

The frequency and severity of ED are relevant in outpatients with sexual complaints and those with chronic comorbidities. Despite limitations, mCCI may be considered a reliable tool to assess the overall burden of multiple chronic conditions in patients with comorbidities.

CONCLUSION

ED is a reliable proxy of overall male health. Further studies are needed to confirm this potential application.

摘要

背景

勃起功能障碍（ED）的患病率随慢性病数量和严重程度的增加而上升。

目的

本横断面研究评估了患有多种慢性病患者中ED的发生频率和严重程度。

方法

采用5项国际勃起功能指数问卷（IIEF-5）对ED进行诊断和分类。使用Charlson合并症指数（CCI）评估慢性合并症的负担。主要结局是根据CCI严重程度评估ED发生频率。次要结局包括评估：1）IIEF-5与总睾酮（TT）之间的相关性；2）CCI与TT之间的相关性；3）IIEF-5与CCI之间的相关性。最后，比较了CCI和改良CCI（mCCI）的性能。