GSK, Istanbul, Turkey.
GSK, Cairo, Egypt.
Hum Vaccin Immunother. 2022 Nov 30;18(5):2073146. doi: 10.1080/21645515.2022.2073146. Epub 2022 May 26.
With 583 million inhabitants, the Eastern Mediterranean Region (EMR) is a worldwide hub for travel, migration, and food trade. However, there is a scarcity of data on the epidemiology of the hepatitis A virus (HAV).
The MEDLINE and grey literature were systematically searched for HAV epidemiological data relevant to the EMR region published between 1980 and 2020 in English, French, or Arabic.
Overall, 123 publications were extracted. The proportion of HAV cases among acute viral hepatitis cases was high. HAV seroprevalence rate ranged from 5.7% to 100.0% and it was decreasing over time while the average age at infection increased.
In the EMR, HAV remains a significant cause of acute viral hepatitis. The observed endemicity shift will likely increase disease burden as the population ages. Vaccinating children and adopting sanitary measures are still essential to disease prevention; vaccinating at-risk groups might reduce disease burden even further.
拥有 5.83 亿人口的东地中海区域（EMR）是全球旅行、移民和食品贸易的中心。然而，有关甲型肝炎病毒（HAV）的流行病学数据却十分匮乏。
我们系统性地检索了 MEDLINE 和灰色文献，以获取 1980 年至 2020 年间以英文、法文或阿拉伯文发表的关于 EMR 地区 HAV 流行病学数据的相关资料。
共提取了 123 篇文献。甲型肝炎病例在急性病毒性肝炎病例中的比例较高。HAV 血清流行率范围为 5.7%至 100.0%，且随着时间的推移呈下降趋势，而感染的平均年龄呈上升趋势。
在 EMR，HAV 仍然是急性病毒性肝炎的一个重要病因。随着人口老龄化，观察到的地方性流行转变可能会增加疾病负担。为儿童接种疫苗和采取卫生措施仍然是疾病预防的关键；为高危人群接种疫苗可能会进一步减轻疾病负担。
