Mental Health Center, Shantou University Medical College, North Taishan Road, Shantou, 515065, Guangdong Province, China.
Department of Preventive Medicine, Shantou University Medical College, Shantou, 515041, Guangdong Province, China.
Environ Pollut. 2022 Aug 15;307:119518. doi: 10.1016/j.envpol.2022.119518. Epub 2022 May 23.
Environmental heavy metal exposure has been considered to be the risk factor for neurodevelopmental disorders in children. However, the available data on the associations between multiple metals exposure and the risk of dyslexia in China are limited. The purpose of our study was to examine the associations between urinary metal concentrations and Chinese dyslexia risk. A total of 56 Chinese dyslexics and 60 typically developing children were recruited. The urinary concentration of 13 metals were measured by inductively coupled plasma-mass spectrometer (ICP-MS). Binary logistic regression and the Probit extension of Bayesian kernel machine regression (BKMR-P) were used to explore the associations between multiple metal exposure and the risk of Chinese dyslexia. Our results indicated that Co, Zn and Pb were significantly associated with Chinese dyslexia in the multiple-metal exposure model. After adjusting the covariates, a positive association was observed between Pb and the risk of Chinese dyslexia, with the odds ratio (OR) in the highest quartiles of 6.81 (95%CI: 1.07-43.19; p-trend = 0.024). Co and Zn were negatively associated with the risk of Chinese dyslexia. Compared to the lowest quartile, the ORs of Co and Zn in the highest quartile are 0.13 (95%CI: 0.02-0.72; p-trend = 0.026) and 0.18 (95%CI: 0.04-0.88; p-trend = 0.038), respectively. In addition, BKMR-P analysis indicated that with the cumulative level across Co, Zn and Pb increased, the risk of Chinese dyslexia gradually declined and then rebounded, albeit non-significantly, and Pb was the major contributor in this association. In general, the urinary concentrations of Co, Zn and Pb were significantly associated with Chinese dyslexia. More prospective studies are needed to confirm the health effects of multiple metals exposure in children with Chinese dyslexia.
环境重金属暴露被认为是儿童神经发育障碍的危险因素。然而，目前在中国，关于多种金属暴露与阅读障碍风险之间的关系的可用数据有限。我们的研究目的是检验尿液中金属浓度与中国阅读障碍风险之间的关系。共招募了 56 名中国阅读障碍者和 60 名正常发育儿童。采用电感耦合等离子体质谱仪（ICP-MS）测量 13 种金属的尿液浓度。采用二元逻辑回归和贝叶斯核机器回归（BKMR-P）的概率扩展来探讨多种金属暴露与中国阅读障碍风险之间的关系。我们的结果表明，在多金属暴露模型中，Co、Zn 和 Pb 与中国阅读障碍显著相关。在调整协变量后，Pb 与中国阅读障碍的风险呈正相关，最高四分位数的比值比（OR）为 6.81（95%CI：1.07-43.19；p-trend=0.024）。Co 和 Zn 与中国阅读障碍的风险呈负相关。与最低四分位数相比，Co 和 Zn 最高四分位数的 OR 分别为 0.13（95%CI：0.02-0.72；p-trend=0.026）和 0.18（95%CI：0.04-0.88；p-trend=0.038）。此外，BKMR-P 分析表明，随着 Co、Zn 和 Pb 的累积水平增加，中国阅读障碍的风险逐渐下降，然后略有回升，但无统计学意义，且 Pb 是该关联的主要贡献者。总体而言，Co、Zn 和 Pb 的尿液浓度与中国阅读障碍显著相关。需要更多的前瞻性研究来证实儿童多种金属暴露对健康的影响。
