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免疫功能正常宿主的非结核分枝杆菌性胸骨髓炎: 一种罕见表现

Non-tuberculous mycobacterial thoracic osteomyelitis in an immunocompetent host: a rare presentation of .

机构信息

Department of Internal Medicine, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA

Department of Infectious Diseases, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

出版信息

BMJ Case Rep. 2022 May 26;15(5):e249629. doi: 10.1136/bcr-2022-249629.

Abstract

An immunocompetent man in his 40s presented with 3 months of mid-thoracic back pain which progressed to include progressive paraesthesias and lower extremity weakness. Investigations revealed thoracic spine osteomyelitis with signs of cord compression. He underwent neurosurgical intervention, including laminectomy, spinal cord decompression and partial resection of an epidural mass. Initial intraoperative biopsy and surgical pathology results were concerning for an acid-fast bacillus as the causative pathogen, and the patient was given empiric therapy for presumed However, microbiology speciation revealed the presence of the non-tuberculous mycobacterium (NTM) , which resulted in an alteration of his antimicrobial therapy. This case highlights the importance of considering NTM as a possible aetiology of spinal osteomyelitis, even among immunocompetent individuals or in low-prevalence regions.

摘要

一位 40 多岁免疫功能正常的男性出现了 3 个月的胸中部背痛,随后进展为进行性感觉异常和下肢无力。检查发现胸段脊柱骨髓炎,伴有脊髓压迫迹象。他接受了神经外科干预,包括椎板切除术、脊髓减压和硬膜外肿块部分切除术。最初的术中活检和手术病理学结果提示可能是导致病原体的抗酸杆菌,因此患者接受了经验性治疗。然而,微生物学分型显示存在非结核分枝杆菌(NTM),这导致他的抗菌治疗发生了改变。这个病例强调了即使在免疫功能正常的个体或低流行地区,也应考虑 NTM 作为脊柱骨髓炎的一个可能病因。

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