Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
Medical Care Line and Research Care Line, Houston VA HSR&D Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA.
Occup Environ Med. 2022 Aug;79(8):543-549. doi: 10.1136/oemed-2022-108212. Epub 2022 May 26.
Occupations involving greater physical activity may increase risk for knee osteoarthritis (OA). Existing studies have not evaluated work-related physical activity before OA onset. Hence, we aimed to evaluate the association between work-related physical activity and knee OA incidence.
We performed a person-based longitudinal study using Osteoarthritis Initiative (OAI) data among people who volunteered or worked for pay without baseline radiographic knee OA or knee pain. Bilateral knee radiographs were obtained at baseline and annual follow-ups. We defined radiographic OA as Kellgren-Lawrence grade ≥2. Questions from the Physical Activity Scale for the Elderly at baseline and annual OAI visits provided information about work-related physical activity level and hours. We performed logistic regression with work-related physical activity level ( , , ) and hours as predictors. The outcome was incident person-based radiographic OA within the ensuing 12 months, over 48 months.
Among 951 participants (2819 observations), higher work-related physical activity levels had greater adjusted ORs for incident radiographic OA (people with jobs with : 1.11 (0.60-2.08), and : 1.90 (1.03-3.52), when compared with those with ). There was no association between number of hours worked and incident radiographic OA.
People performing work that require walking while handling some materials have greater odds of incident knee OA than those with jobs mostly involving sitting. Strategies are needed to mitigate risk factors predisposing them to radiographic OA.
需要更多体力活动的职业可能会增加膝骨关节炎（OA）的风险。现有的研究尚未评估 OA 发病前与工作相关的体力活动。因此，我们旨在评估与工作相关的体力活动与膝骨关节炎发病之间的关系。
我们使用 Osteoarthritis Initiative（OAI）数据进行了基于个体的纵向研究，研究对象为没有基线放射学膝骨关节炎或膝关节疼痛的志愿者或有薪工作者。在基线和每年的随访中都获得了双侧膝关节的放射照片。我们将放射学 OA 定义为 Kellgren-Lawrence 分级≥2。基线和每年 OAI 就诊时的《老年人体力活动量表》中的问题提供了与工作相关的体力活动水平和时间的信息。我们使用逻辑回归，以工作相关的体力活动水平（低、中、高）和小时数作为预测因子。结果是在接下来的 12 个月内，48 个月内出现以个体为基础的放射学 OA。
在 951 名参与者（2819 次观察）中，更高的工作相关体力活动水平与放射学 OA 的发病风险具有更高的校正比值比（从事：1.11（0.60-2.08）和 ：1.90（1.03-3.52）的人，与从事 ：1.90（1.03-3.52）的人相比）。工作时间与放射学 OA 的发病无关。
与从事主要涉及坐立工作的人相比，从事需要走动同时搬运一些材料的工作的人患膝骨关节炎的几率更高。需要采取策略来减轻使他们易患放射学 OA 的危险因素。
