Reichenbach A, Neumann M, Brückner G
Neurosci Lett. 1987 Jan 2;73(1):95-100. doi: 10.1016/0304-3940(87)90038-3.
In thick sections of Golgi-impregnated late fetal rat brains, radial glial cells were measured for both length and diameter of their main (basal) processes. The process diameter was found to decrease proportionally to the square root of cell length; thus, the cytoplasm volume remained fairly constant for cells in the range of lengths studied (100-2500 microns). The measured data were used for calculation of the cell's space constant lambda in order to estimate their capability to carry spatial buffering K+ currents. These calculations show that long and slender cells are unable to perform sufficient K+ clearance by such currents. This supports the hypothesis that perinatally when the maturing neurons release enhanced K+ during electrical activity, such long thin cells are subject to long-lasting depolarizations and, thereby, forced to undergo mitotic cell division transforming them into multipolar astrocytes.
在高尔基染色的晚期胎鼠大脑厚切片中，对放射状胶质细胞主要（基底）突起的长度和直径进行了测量。发现突起直径与细胞长度的平方根成比例减小；因此，在所研究的长度范围内（100 - 2500微米），细胞的细胞质体积保持相当恒定。测量数据用于计算细胞的空间常数λ，以估计它们携带空间缓冲钾离子电流的能力。这些计算表明，长而细的细胞无法通过这种电流进行足够的钾离子清除。这支持了以下假设：在围产期，当成熟神经元在电活动期间释放增强的钾离子时，这种长而细的细胞会经历持久的去极化，从而被迫进行有丝分裂细胞分裂，将它们转化为多极星形胶质细胞。
