Kim Duhoe, Seo Jaehun, Ha Kyoung Hwa, Kim Dae Jung
Ajou University Hospital, Suwon, Korea.
Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Korea.
J Obes Metab Syndr. 2022 Jun 30;31(2):187-195. doi: 10.7570/jomes22007. Epub 2022 May 27.
We investigated the association between changes in physical activity and the risk of a major adverse cardiovascular event (MACE) in people with newly diagnosed diabetes.
Using a nationwide database, we identified 8,596 people with newly diagnosed diabetes who underwent national health examinations within a year before and after a diabetes diagnosis. Cox proportional hazards models, hazard ratios (HRs) and 95% confidence intervals (CIs) for MACE risks were calculated according to changes in physical activity before and after a diagnosis of diabetes.
During a median follow-up of 2.3 years, study participants who engaged in sustained physical activity after a diagnosis of diabetes had a 34% lower MACE risk compared to those with sustained inactivity (HR, 0.66; 95% CI, 0.44-0.98). An advantage was observed in those with a history of cardiovascular disease, although this was of borderline statistical significance (HR, 0.63; 95% CI, 0.40-1.01; =0.054). In people considered obese, physical activity was significantly associated with a decreased risk of a MACE, regardless of the period preceding and following the diabetes diagnosis. Those who became inactive to active had the lowest risk of a MACE (HR, 0.38; 95% CI, 0.18-0.79).
Maintaining active physical activity before and after a diagnosis of diabetes is essential to preventing cardiovascular disease. Early intervention strategies are necessary to promote physical activity and exercise routines after a diagnosis of diabetes in people with obesity and those with pre-existing cardiovascular disease.
我们调查了新诊断糖尿病患者身体活动变化与主要不良心血管事件（MACE）风险之间的关联。
利用全国性数据库，我们确定了8596名新诊断的糖尿病患者，他们在糖尿病诊断前后一年内接受了全国健康检查。根据糖尿病诊断前后身体活动的变化，计算MACE风险的Cox比例风险模型、风险比（HR）和95%置信区间（CI）。
在中位随访2.3年期间，与持续不活动的参与者相比，糖尿病诊断后持续进行身体活动的研究参与者发生MACE的风险降低了34%（HR，0.66；95%CI，0.44 - 0.98）。在有心血管疾病史的患者中观察到了益处，尽管这在统计学上接近显著性（HR，0.63；95%CI，0.40 - 1.01；P = 0.054）。在被认为肥胖的人群中，无论糖尿病诊断前后的时期如何，身体活动与MACE风险降低显著相关。从不活动变为活动的人发生MACE的风险最低（HR，0.38；95%CI，0.18 - 0.79）。
糖尿病诊断前后保持积极的身体活动对于预防心血管疾病至关重要。对于肥胖患者和已有心血管疾病的患者，在糖尿病诊断后促进身体活动和锻炼习惯的早期干预策略是必要的。
