三磷酸腺苷（ATP）和三磷酸鸟苷（GTP）对嗅觉反应至关重要。

ATP and GTP are essential for olfactory response.

作者信息

Vodyanoy V, Vodyanoy I

出版信息

Neurosci Lett. 1987 Jan 27;73(3):253-8. doi: 10.1016/0304-3940(87)90254-0.

Abstract

The steady-state conductance of planar bimolecular lipid membranes (BLMs) modified with rat olfactory epithelial homogenate (ROH) becomes sensitive to very low concentrations of odorant in the presence of adenosine triphosphate (ATP) and guanosine triphosphate (GTP). The chemosensitivity is not observed when ATP and GTP are absent. Adenosine 3',5'monophosphate (cAMP) mimics the effect of the odorant. Effects of odorants and cAMP are dose dependent. These data are consistent with the hypothesis that cAMP is a second messenger in the initial steps of olfactory transduction.

摘要

在用大鼠嗅觉上皮匀浆（ROH）修饰的平面双分子脂质膜（BLM）中，在存在三磷酸腺苷（ATP）和三磷酸鸟苷（GTP）的情况下，其稳态电导对极低浓度的气味剂变得敏感。当不存在ATP和GTP时，未观察到化学敏感性。3',5'-单磷酸腺苷（cAMP）模拟气味剂的作用。气味剂和cAMP的作用呈剂量依赖性。这些数据与cAMP是嗅觉转导初始步骤中的第二信使这一假设一致。