Ward L C, Tiernan J M, Hayling N, Mason S
Neurosci Lett. 1987 Mar 9;74(3):353-7. doi: 10.1016/0304-3940(87)90323-5.
The effect of ethanol consumption (27% of energy intake) for 21 days, on protein synthesis and degradation in subcellular fractions of rat brain was investigated using the Na2(14)CO3 labelling procedure. Ethanol administration elicited an increase in the rate of protein synthesis in all fractions which was accompanied by an increase of similar magnitude in the rate of breakdown. These results imply that whilst ethanol increases the rate of protein turnover it is without effect on the rate of protein accretion.
采用 Na2(14)CO3 标记法，研究了大鼠脑亚细胞组分中乙醇摄入（占能量摄入的 27%）21 天对蛋白质合成和降解的影响。给予乙醇后，所有组分中的蛋白质合成速率均增加，同时分解速率也有相似幅度的增加。这些结果表明，虽然乙醇增加了蛋白质周转速率，但对蛋白质积累速率没有影响。
