School of Psychology, Shaanxi Normal University, Xi'an, 710062, China.
MOE Key Laboratory of Modern Teaching Technology, Shaanxi Normal University, Xi'an, 710062, China.
Learn Behav. 2022 Sep;50(3):267-268. doi: 10.3758/s13420-022-00526-4. Epub 2022 May 26.
Smith et al. in Nature Communications, 12, 5121, (2021) provided evidence to challenge the simple dichotomy that learning of actions and expression of habitual behaviors are processed separately in dorsomedial (DMS) and dorsolateral striatum (DLS) by demonstrating that D2 receptor-expressing medium spiny neurons (D2-MSNs) in anterior DLS could modulate newly learned action, except for its involvement in the expression of habitual actions. Here we review recent advances and introduce a valuable addition to the traditional hypothesis by taking into account the common ligand of D1 and D2 neurons, dopamine.
史密斯等人在《自然通讯》第 12 卷第 5121 期（2021 年）发表的研究结果，通过证明前背侧纹状体中的 D2 受体表达的中间神经元（D2-MSNs）可以调节新习得的动作，除了其参与习惯性动作的表达外，从而对动作的学习和习惯性行为的表达是在背侧中隔核（DMS）和背外侧纹状体（DLS）中分别进行的这种简单二分法提出了挑战。在这里，我们回顾了最近的进展，并通过考虑 D1 和 D2 神经元的共同配体多巴胺，对传统假说进行了有价值的补充。
