Um Yoo Hyun, Wang Sheng-Min, Kang Dong Woo, Kim Nak-Young, Lim Hyun Kook
Department of Psychiatry, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Department of Psychiatry, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Front Psychiatry. 2022 May 10;13:875227. doi: 10.3389/fpsyt.2022.875227. eCollection 2022.
Transdermal trigeminal electrical neuromodulation (TTEN) is a novel treatment modality that is known for noradrenergic modulation through the trigeminal nerve and locus coeruleus (LC). This study aimed to demonstrate the alterations of LC functional connectivity (FC) in patients with insomnia after a 4-week TTEN.
The Cefaly device targeting the ophthalmic division of the trigeminal nerve was applied to a total of 12 patients with insomnia to monitor for the effects of TTEN. All the patients went through a 4-week daily 20 min TTEN sessions before bedtime. Baseline and post-TTEN demographic data, polysomnography (PSG) parameters, and insomnia severity index (ISI) were attained. Data from pre- and post-intervention resting-state functional magnetic resonance imaging (MRI) were collected. LC FC differences were measured between the pre-and post-TTEN groups through seed-to-voxel analysis. Correlation analyses were conducted between LC FC changes after TTEN, ISI score changes, and PSG parameter changes.
There was a significantly decreased LC FC with occipital and temporal cortices after a 4-week TTEN. However, there was no significant correlation between LC FC, ISI score changes, and PSG parameter changes.
By targeting hyperarousal symptoms of insomnia, TTEN can be a promising intervention that can modulate LC FC in patients with insomnia patients. The data presented in the study are from a study exploring the effect of TTEN on insomnia (www.clinicaltrials.gov, NCT04838067).
经皮三叉神经电调制（TTEN）是一种新型治疗方式，以通过三叉神经和蓝斑（LC）进行去甲肾上腺素能调制而闻名。本研究旨在证明失眠患者在接受4周TTEN治疗后蓝斑功能连接（FC）的变化。
将针对三叉神经眼支的Cefaly设备应用于总共12名失眠患者，以监测TTEN的效果。所有患者在睡前进行为期4周的每日20分钟TTEN治疗。获取基线和TTEN治疗后的人口统计学数据、多导睡眠图（PSG）参数和失眠严重程度指数（ISI）。收集干预前和干预后静息态功能磁共振成像（MRI）的数据。通过种子体素分析测量TTEN治疗前后组间的蓝斑FC差异。对TTEN治疗后蓝斑FC变化、ISI评分变化和PSG参数变化进行相关性分析。
经过4周的TTEN治疗后，蓝斑与枕叶和颞叶皮质的FC显著降低。然而，蓝斑FC、ISI评分变化和PSG参数变化之间没有显著相关性。
通过针对失眠的高觉醒症状，TTEN可能是一种有前景的干预措施，可以调节失眠患者的蓝斑FC。本研究中的数据来自一项探索TTEN对失眠影响的研究（www.clinicaltrials.gov，NCT04838067）。
