Larsen H C
ORL J Otorhinolaryngol Relat Spec. 1987;49(1):17-21. doi: 10.1159/000275901.
The cochlear and cerebral blood flow were simultaneously measured with the microsphere method in albino rabbits before and after administration of prazosin (0.5 mg/kg body weight) and before and during an increase in intracranial pressure (ICP) and intracochlear pressure. Increments in ICP were induced by intracranial infusion of Ringer solution prewarmed to body temperature. The increments were accompanied by an intravenous administration of prazosin to abolish the Cushing effect. The cochlear blood flow was unaffected by the intravenously administered prazosin. A decrease was found when the perfusion pressure of the cochlear, i.e. mean arterial blood pressure minus ICP fell below 5 kPa.
采用微球法，在白化兔给予哌唑嗪（0.5mg/kg体重）前后以及颅内压（ICP）和耳蜗内压升高之前及期间，同时测量耳蜗和脑血流量。通过向颅内输注预热至体温的林格液诱导ICP升高。在静脉注射哌唑嗪以消除库欣效应的同时，进行上述ICP升高操作。静脉注射哌唑嗪对耳蜗血流量无影响。当耳蜗灌注压，即平均动脉血压减去ICP降至5kPa以下时，耳蜗血流量会减少。
