Jensen E B, Fjeldborg O, Lamm L U
Scand J Urol Nephrol Suppl. 1977(42):166-9.
A statistical method which accounts for the heterogeneity of clinical materials is presented and applied to a material of necrokidney transplantations. It is concluded that the recipient sex and the period in which the transplantation was performed are the most important factors (best prognosis for female recipients, best programs for transplantations in the first periods) and that the HLA-match grade has a significant influence on graft survival for male recipients and transplantations with short cold ischemia time. The present analysis has furthermore demonstrate the heterogeneity of the material as judged by the associations between factors and the overestimation of the influence of some of the factors by direct comparisons.
本文提出了一种考虑临床材料异质性的统计方法,并将其应用于肾移植坏死材料。得出的结论是,受者性别和移植进行的时期是最重要的因素(女性受者预后最佳,早期移植方案最佳),并且HLA匹配等级对男性受者和冷缺血时间短的移植的移植物存活有显著影响。此外,本分析还证明了材料的异质性,这是通过因素之间的关联以及直接比较对某些因素影响的高估来判断的。