针对奥密克戎及其他关注变异株的严重急性呼吸综合征冠状病毒2抗原检测快速诊断测试的性能
Performance of SARS-CoV-2 Antigen-Detecting Rapid Diagnostic Tests for Omicron and Other Variants of Concern.
作者信息
Raïch-Regué Dàlia, Muñoz-Basagoiti Jordana, Perez-Zsolt Daniel, Noguera-Julian Marc, Pradenas Edwards, Riveira-Muñoz Eva, Giménez Neus, Carabaza Assumpta, Giménez Francesc, Saludes Verónica, Martró Elisa, Robert Neus, Blanco Ignacio, Paredes Roger, Ruiz Lidia, Ballana Ester, Clotet Bonaventura, Blanco Julià, Izquierdo-Useros Nuria
机构信息
IrsiCaixa AIDS Research Institute, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.
AIDS and Infectious Deseases Department, University of Vic-Central University of Catalonia (UVic-UCC), Vic, Spain.
出版信息
Front Microbiol. 2022 May 10;13:810576. doi: 10.3389/fmicb.2022.810576. eCollection 2022.
The SARS-CoV-2 antigen-detecting rapid diagnostic test (Ag-RDTs) is an easy-to-use diagnostic tool to identify the contagious individuals and reduce the new infections. However, to be effective, Ag-RDTs require the detection of distinct variants of concern (VOC) with high analytical sensitivity. Here, we found that the VOC diverge at the nucleocapsid protein used by four commercial Ag-RDTs for the viral detection. Relative to the original D614G variant, there was a 10-fold loss of detection for the Delta and Alpha variants in certain Ag-RDTs, a reduction above the threshold required to isolate the viable virus. However, Beta and Omicron variants did not lose the detection capacity. As the new VOC arise, successful contact tracing requires continuous monitoring of Ag-RDTs performance.
严重急性呼吸综合征冠状病毒2抗原检测快速诊断测试（Ag-RDTs）是一种易于使用的诊断工具，用于识别具有传染性的个体并减少新感染。然而，为了有效，Ag-RDTs需要以高分析灵敏度检测不同的关注变体（VOC）。在这里，我们发现VOC在四种用于病毒检测的商用Ag-RDTs所使用的核衣壳蛋白上存在差异。相对于原始的D614G变体，某些Ag-RDTs对Delta和Alpha变体的检测能力下降了10倍，这一下降幅度超过了分离活病毒所需的阈值。然而，Beta和Omicron变体并未丧失检测能力。随着新的VOC出现，成功的接触者追踪需要持续监测Ag-RDTs的性能。
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