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高效液相色谱法检测糖化血红蛋白在暴发型 1 型糖尿病发病诊断中的陷阱。

A pitfall in hemoglobin A1c measurement with high performance liquid chromatography method in the diagnosis of onset of fulminant type 1 diabetes mellitus.

机构信息

Department of Clinical Laboratory, Kawasaki Medical School General Medical Center, Okayama, Japan.

Department of General Internal Medicine 1, Kawasaki Medical School, Okayama, Japan.

出版信息

J Diabetes Investig. 2022 Nov;13(11):1943-1944. doi: 10.1111/jdi.13834. Epub 2022 May 27.

DOI:10.1111/jdi.13834
PMID:35620974
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9623534/
Abstract

We showed a case with the onset of fulminant type 1 diabetes mellitus (FT1DM) whose HbA1c could not be measured with HPLC method. We think that the reason why his HbA1c was not be detected was associated with the presence of labile hemoglobin A1c (LHbA1c). These result mean that it is possible that LHbA1c can bring about a pitfall on HPLC method in diagnosis of onset of FT1DM.

摘要

我们展示了一例暴发型 1 型糖尿病（FT1DM）患者，其 HbA1c 无法用 HPLC 法测量。我们认为他的 HbA1c 未被检测到的原因与不稳定的血红蛋白 A1c（LHbA1c）的存在有关。这些结果意味着 LHbA1c 可能会在 HPLC 法诊断 FT1DM 发病时带来陷阱。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/9623534/31411befc2f3/JDI-13-1943-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/9623534/31411befc2f3/JDI-13-1943-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c2a/9623534/31411befc2f3/JDI-13-1943-g002.jpg

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本文引用的文献

1
First evaluation of Capillarys 2 Flex Piercing® (Sebia) as a new analyzer for HbA1c assay by capillary electrophoresis.毛细管电泳法新分析仪 Capillarys 2 Flex Piercing®（Sebia）用于测定糖化血红蛋白的首次评估。
Clin Chem Lab Med. 2012 Oct 1;50(10):1769-75. doi: 10.1515/cclm-2012-0017.
2
Characterization of unstable hemoglobin A1c complexes by dynamic capillary isoelectric focusing.采用动态毛细管等电聚焦技术对不稳定血红蛋白 A1c 复合物进行表征。
Anal Biochem. 2012 May 15;424(2):149-55. doi: 10.1016/j.ab.2012.02.011. Epub 2012 Feb 25.
3
HbA1c: how do we measure it and what does it mean?
糖化血红蛋白（HbA1c）：我们如何测量它以及它意味着什么？
Curr Opin Endocrinol Diabetes Obes. 2009 Apr;16(2):113-8. doi: 10.1097/MED.0b013e328327728d.
4
A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. Osaka IDDM Study Group.一种以起病迅速且无糖尿病相关抗体为特征的1型糖尿病新亚型。大阪青少年糖尿病研究组。
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