Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center, Houston, TX, USA.
Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Virchows Arch. 2022 Oct;481(4):659-663. doi: 10.1007/s00428-022-03348-x. Epub 2022 May 27.
CD2 is a costimulatory protein expressed in all mature T/NK-cells, in particular memory T-cells. CD58 (or LFA-3) is the receptor for CD2 and is ubiquitously expressed. CD2-CD58 interaction has key functions in T-cell activation and organization of the immunological synapse between T- and antigen-presenting cells. Cancer cells have developed multiple mechanisms to evade immune surveillance. Loss of CD58 expression is one frequently reported in diffuse large B-cell lymphomas (DLBCL). On the other hand, in non-hematological neoplasms, tumor infiltrating lymphocytes (TILs) with reduced expression of CD2 have been associated with defective cytotoxicity and T-cell exhaustion. Here, we reported a case of DLBCL involving the jejunal mucosa associated with a rim of cytotoxic reactive T-cells with features of immune evasion (CD2- and TCR-) and T-cell exhaustion (PD1 + high). This case likely exemplifies a previously unrecognized immune evasion mechanism in lymphoma involving a decreased CD2 expression in the lymphoma-associated T-cells.
CD2 是一种在所有成熟的 T/NK 细胞中表达的共刺激蛋白，特别是记忆 T 细胞。CD58（或 LFA-3）是 CD2 的受体，广泛表达。CD2-CD58 相互作用在 T 细胞激活和 T 细胞与抗原呈递细胞之间免疫突触的组织中具有关键功能。癌细胞已经开发出多种逃避免疫监视的机制。CD58 表达缺失是弥漫性大 B 细胞淋巴瘤（DLBCL）中经常报道的一种。另一方面，在非血液系统肿瘤中，表达降低的肿瘤浸润淋巴细胞（TIL）与细胞毒性缺陷和 T 细胞衰竭有关。在这里，我们报告了一例累及空肠黏膜的 DLBCL，伴有免疫逃避（CD2-和 TCR-）和 T 细胞衰竭（PD1+高）特征的反应性杀伤性 T 细胞环。这种情况可能代表了淋巴瘤中一种以前未被认识的免疫逃避机制，涉及淋巴瘤相关 T 细胞中 CD2 表达的降低。
