Research Institute of Cardiology, Tomsk National Research Medical Center, Tomsk, Russia.
Bull Exp Biol Med. 2022 May;173(1):33-36. doi: 10.1007/s10517-022-05487-2. Epub 2022 May 27.
In rats anesthetized with α-chloralose, coronary artery occlusion (45 min) and reperfusion (120 min) were modeled. The selective δ-opioid receptor agonist deltorphin II was administered 5 min before reperfusion. Protein kinase C inhibitor chelerythrine, AMP-activated protein kinase inhibitor compound C, and ATP-sensitive K channel blockers glibenclamide, 5-hydroxydecanoate, and HMR 1098 were administered 10 min before reperfusion. It was found that the infarct-limiting effect of deltorphin II is associated with activation of protein kinase C and opening of sarcolemmal ATP-sensitive K channel.
在α-氯醛糖麻醉的大鼠中，建立了冠状动脉闭塞（45 分钟）和再灌注（120 分钟）模型。在再灌注前 5 分钟给予选择性 δ-阿片受体激动剂δ-吗啡肽 II。蛋白激酶 C 抑制剂桔霉素、AMP 激活蛋白激酶抑制剂化合物 C 以及三磷酸腺苷敏感钾通道阻滞剂格列本脲、5-羟葵酸和 HMR 1098 在再灌注前 10 分钟给予。结果发现，δ-吗啡肽 II 的梗死限制作用与蛋白激酶 C 的激活和肌浆网三磷酸腺苷敏感钾通道的开放有关。
