在盐酸中用过氧化氢氧化嘧啶碱及其衍生物。
Oxidation of pyrimidine bases and their derivatives with hydrogen peroxide in hydrochloric acid.
作者信息
Itahara T, Tada M, Ide N
出版信息
Nucleic Acids Symp Ser. 1986(17):17-20.
PMID:3562263
Abstract
Oxidation of cytosine with H2O2 in 1 N-HCl gave 5-chlorocytosine and 5-chlorouracil. The reaction of uracil gave 5-chlorouracil. Treatment of thymine with H2O2 in 0.1 N-HCl gave 5-chloro-6-hydroperoxy-5,6-dihydrothymine, while the reaction in 1 N-HCl gave 5-chloro-6-hydroxy-5,6-dihydrothymine. Heating of 5-chloro-6-hydroperoxy-5,6-dihydrothymine in water gave 5-chloro-5-methylbarbituric acid.
摘要
在1N - HCl中用H₂O₂氧化胞嘧啶得到5 - 氯胞嘧啶和5 - 氯尿嘧啶。尿嘧啶的反应得到5 - 氯尿嘧啶。在0.1N - HCl中用H₂O₂处理胸腺嘧啶得到5 - 氯 - 6 - 氢过氧基 - 5,6 - 二氢胸腺嘧啶，而在1N - HCl中的反应得到5 - 氯 - 6 - 羟基 - 5,6 - 二氢胸腺嘧啶。5 - 氯 - 6 - 氢过氧基 - 5,6 - 二氢胸腺嘧啶在水中加热得到5 - 氯 - 5 - 甲基巴比妥酸。
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