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伊文思蓝对各种DNA聚合酶的不同抑制作用。

Differential inhibitory effects of Evans blue on various DNA polymerases.

作者信息

Nakane H, Balzarini J, De Clercq E, Ono K

出版信息

Nucleic Acids Symp Ser. 1986(17):183-6.

PMID:3562264
Abstract

Evans Blue, an anionic dye which has been found to inhibit the replication of human immunodeficiency virus, proved also inhibitory to the DNA polymerases alpha and beta. The mode of inhibition was competitive with respect to the template X primer, and noncompetitive with respect to the deoxynucleoside triphosphate substrates. The inhibitory effect of Evans Blue on DNA polymerases is discussed in relation to that of suramin.

摘要

伊文思蓝是一种阴离子染料，已发现它能抑制人类免疫缺陷病毒的复制，它对DNA聚合酶α和β也有抑制作用。抑制模式在模板X引物方面是竞争性的，在脱氧核苷三磷酸底物方面是非竞争性的。本文结合苏拉明的抑制作用对伊文思蓝对DNA聚合酶的抑制作用进行了讨论。

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