8-(2”-羟基乙氧基)腺苷-5',2”-磷酸衍生物的合成
Synthesis of 8-(2"-hydroxyethoxy)adenosine-5',2"-phosphate derivative.
作者信息
Maruyama T, Adachi Y, Honjo M
出版信息
Nucleic Acids Symp Ser. 1986(17):61-3.
PMID:3562277
Abstract
Reaction of 8-bromo-2',3'-O-isopropylidene-5'-O-(tetrahydropyran-2-yl) adenosine (Ib) with lithium 2-(tetrahydropyran-2-yloxy) ethoxide, followed by removal of the tetrahydropyran-2-yl groups, afforded 8-(2''-hydroxyethoxy)-2',3'-O-isopropylideneadenosine (II). Successive treatment of II with n-butyllithium and with methyl dichlorophosphate provided the 5',2''-(methyl phosphate) derivative (IIIa and IIIb).
摘要
8-溴-2',3'-O-异亚丙基-5'-O-(四氢吡喃-2-基)腺苷（Ib）与2-(四氢吡喃-2-基氧基)乙醇锂反应，随后去除四氢吡喃-2-基，得到8-(2''-羟基乙氧基)-2',3'-O-异亚丙基腺苷（II）。II依次用正丁基锂和二氯磷酸甲酯处理，得到5',2''-(甲基磷酸)衍生物（IIIa和IIIb）。
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