Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232-2363, USA.
Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232-2363, USA.
Eur J Cell Biol. 2022 Jun-Aug;101(3):151239. doi: 10.1016/j.ejcb.2022.151239. Epub 2022 May 21.
Approximately 170 RNA modifications have been identified and these are critical for determining the fate and function of cellular RNAs. Similar to human transcripts, viral RNAs possess an extensive RNA modification landscape. While initial efforts largely focused on investigating the RNA modification landscape in the context of RNA virus infection, a growing body of work has explored the impact of RNA modifications on DNA virus biology. These studies have revealed roles for RNA modifications in DNA virus infection, including gene regulation and viral pathogenesis. In this review, we will discuss the current knowledge on how RNA modifications impact DNA virus biology.
大约有 170 种 RNA 修饰被鉴定出来，这些修饰对于确定细胞 RNA 的命运和功能至关重要。与人类转录本类似，病毒 RNA 具有广泛的 RNA 修饰景观。虽然最初的研究主要集中在调查 RNA 修饰在 RNA 病毒感染背景下的景观，但越来越多的研究探索了 RNA 修饰对 DNA 病毒生物学的影响。这些研究揭示了 RNA 修饰在 DNA 病毒感染中的作用，包括基因调控和病毒发病机制。在这篇综述中，我们将讨论目前关于 RNA 修饰如何影响 DNA 病毒生物学的知识。
