Ott H
Scand J Rheumatol Suppl. 1978(21):5-7. doi: 10.3109/03009747809095665.
Chemical modification of 1-methyl-4-phenyl-2 (1H)-quinazolinone, a new lead in the area of non-steroidal anti-inflammatory agents, has led to 1-isopropyl-4-phenyl-7-methyl-2 (1H)-quinazolinone, proquazone. The overall anti-inflammatory profile of proquazone compares well with indomethacin qualitatively and quantitatively. It is particularly noteworthy that proquazone is the first potent anti-inflammatory drug of a non-acidic nature.
1-甲基-4-苯基-2（1H）-喹唑啉酮是非甾体抗炎药领域的一种新先导化合物，对其进行化学修饰后得到了1-异丙基-4-苯基-7-甲基-2（1H）-喹唑啉酮，即丙喹宗。丙喹宗的整体抗炎特性在定性和定量方面与吲哚美辛相当。特别值得注意的是，丙喹宗是第一种具有强效抗炎作用的非酸性药物。
