Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.
Nat Cancer. 2022 May;3(5):522-525. doi: 10.1038/s43018-022-00379-w.
As guidelines, therapies, and literature on cancer variants expand, the lack of consensus variant interpretations impedes clinical applications. CIViC is a public domain, crowd-sourced, and adaptable knowledgebase of evidence for the Clinical Interpretation of Variants in Cancer, designed to reduce barriers to knowledge sharing and alleviate the variant interpretation bottleneck.
随着癌症变异相关指导方针、疗法和文献的不断增加，缺乏共识的变异解释阻碍了临床应用。CIViC 是一个公共领域、众包的、可适应的癌症变异临床解读证据知识库，旨在减少知识共享的障碍，并缓解变异解释瓶颈。
