Gramlich C A, Stripling J S
Pharmacol Biochem Behav. 1987 Jan;26(1):159-65. doi: 10.1016/0091-3057(87)90549-1.
Male Long-Evans rats experienced three convulsions induced by intravenously administered pentylenetetrazol (PTZ) and were then kindled by electrical stimulation of the olfactory bulb or amygdala. Pretreatment with PTZ did not alter the rate of kindling in either site but did enhance the expression of kindled seizures once generalization had occurred (PTZ-treated animals had significantly longer motor seizures, measured by clonus duration, than did saline-treated controls). This suggests that PTZ-induced convulsions have selective effects on areas of the brain that are involved in the expression of the motor seizure. In addition, rats treated with PTZ after kindling had convulsions that were significantly longer in duration than any of their three pre-kindling convulsions, indicating that kindling produced an increased sensitivity to PTZ's convulsant effects. Comparison of this experiment with previous research suggests that the ability of a drug treatment to generate a kindling-like effect is related to the pattern of seizure activity that it produces.
雄性Long-Evans大鼠经静脉注射戊四氮（PTZ）诱发三次惊厥，然后通过电刺激嗅球或杏仁核进行点燃。PTZ预处理并未改变任一部位的点燃速率，但一旦惊厥泛化，确实增强了点燃性癫痫发作的表现（通过阵挛持续时间测量，PTZ处理的动物运动性癫痫发作明显长于生理盐水处理的对照组）。这表明PTZ诱发的惊厥对参与运动性癫痫发作表现的脑区具有选择性作用。此外，点燃后用PTZ处理的大鼠惊厥持续时间明显长于其三次点燃前惊厥中的任何一次，表明点燃使对PTZ惊厥作用的敏感性增加。将该实验与先前研究进行比较表明，药物治疗产生类似点燃效应的能力与其产生的癫痫发作活动模式有关。
