Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 6500017, Japan.
Division of Medical Chemistry, Department of Metabolism and Diseases, Kobe University Graduate School of Health Sciences, Kobe 6540142, Japan.
Biomolecules. 2022 Apr 21;12(5):614. doi: 10.3390/biom12050614.
Pancreatic β-cells are the only type of cells that can control glycemic levels via insulin secretion. Thus, to explore the mechanisms underlying pancreatic β-cell failure, many reports have clarified the roles of important molecules, such as the mechanistic target of rapamycin (mTOR), which is a central regulator of metabolic and nutrient cues. Studies have uncovered the roles of mTOR in the function of β-cells and the progression of diabetes, and they suggest that mTOR has both positive and negative effects on pancreatic β-cells in the development of diabetes.
胰岛 β 细胞是唯一能够通过胰岛素分泌来控制血糖水平的细胞。因此，为了探究胰岛 β 细胞衰竭的机制，许多研究已经阐明了重要分子的作用，如雷帕霉素靶蛋白（mTOR），它是代谢和营养信号的中央调节剂。研究揭示了 mTOR 在 β 细胞功能和糖尿病进展中的作用，并表明 mTOR 在糖尿病的发展过程中对胰岛 β 细胞既有积极影响，也有消极影响。
