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根据免疫组织化学特征分析成人胶质肿瘤的碳水化合物代谢参数

Carbohydrate Metabolism Parameters of Adult Glial Neoplasms According to Immunohistochemical Profile.

作者信息

Obukhova Larisa, Nikiforova Olga, Kontorshchikova Claudia, Medyanik Igor, Orlinskaya Natalya, Grishin Artem, Kontorshchikov Michael, Shchelchkova Natalya

机构信息

Federal State Budgetary Educational Institution of Higher Education, Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, 603005 Nizhny Novgorod, Russia.

出版信息

Biomedicines. 2022 Apr 27;10(5):1007. doi: 10.3390/biomedicines10051007.

DOI:10.3390/biomedicines10051007
PMID:35625744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9138280/
Abstract

This research aimed to investigate the interrelationship of carbohydrate metabolism parameters and immunohistochemical characteristics of glial tumors. Tumor tissue, peritumoral area, and adjacent noncancerous tissue fragments of 20 patients with gliomas of varying degrees of anaplasia were analyzed. The greatest differences in the carbohydrate metabolism compared to adjacent noncancerous tissues were identified in the tumor tissue: reduction in the levels of lactate and glycogen synthase kinase-3β. Significant differences with adjacent noncancerous tissues for the peritumoral zone were not found. The activity of the carbohydrate metabolism enzymes was different depending on the immunohistochemical glioma profile, especially from Ki 67 level. Bioinformatic analysis of the interactions of immunohistochemical markers of gliomas and carbohydrate metabolism enzymes using the databases of STRING, BioGrid, and Signor revealed the presence of biologically significant interactions with glycogen synthase kinase 3β, hexokinase, glucose-6-phosphate dehydrogenase, and transketolase. The established interconnection of glycolysis with methylation of the promoter of O-6-methylguanine-DNA-methyltransferase (MGMT) of gliomas can be used to increase chemotherapy efficiency.

摘要

本研究旨在探讨胶质肿瘤碳水化合物代谢参数与免疫组化特征之间的相互关系。分析了20例不同间变程度胶质瘤患者的肿瘤组织、瘤周区域及相邻非癌组织碎片。与相邻非癌组织相比，肿瘤组织中碳水化合物代谢的差异最为显著：乳酸水平和糖原合酶激酶-3β水平降低。未发现瘤周区域与相邻非癌组织存在显著差异。碳水化合物代谢酶的活性因免疫组化胶质瘤特征而异，尤其是与Ki 67水平有关。利用STRING、BioGrid和Signor数据库对胶质瘤免疫组化标志物与碳水化合物代谢酶的相互作用进行生物信息学分析，结果显示糖原合酶激酶3β、己糖激酶、葡萄糖-6-磷酸脱氢酶和转酮醇酶之间存在生物学上的显著相互作用。已确定的糖酵解与胶质瘤O-6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）启动子甲基化之间的联系可用于提高化疗效率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8179/9138280/aa1c85ccf6ea/biomedicines-10-01007-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8179/9138280/01c9bd047310/biomedicines-10-01007-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8179/9138280/dd79deb5cd81/biomedicines-10-01007-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8179/9138280/24659c209fca/biomedicines-10-01007-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8179/9138280/f951883e0c67/biomedicines-10-01007-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8179/9138280/d95f97b70479/biomedicines-10-01007-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8179/9138280/654e46cb6f6a/biomedicines-10-01007-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8179/9138280/dcc1eb35f804/biomedicines-10-01007-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8179/9138280/e4e564727674/biomedicines-10-01007-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8179/9138280/aa1c85ccf6ea/biomedicines-10-01007-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8179/9138280/01c9bd047310/biomedicines-10-01007-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8179/9138280/dd79deb5cd81/biomedicines-10-01007-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8179/9138280/24659c209fca/biomedicines-10-01007-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8179/9138280/f951883e0c67/biomedicines-10-01007-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8179/9138280/d95f97b70479/biomedicines-10-01007-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8179/9138280/654e46cb6f6a/biomedicines-10-01007-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8179/9138280/dcc1eb35f804/biomedicines-10-01007-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8179/9138280/e4e564727674/biomedicines-10-01007-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8179/9138280/aa1c85ccf6ea/biomedicines-10-01007-g009.jpg

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