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极早产儿的促炎内皮表型：一项初步研究。

Proinflammatory Endothelial Phenotype in Very Preterm Infants: A Pilot Study.

作者信息

Amelio Giacomo S, Provitera Livia, Raffaeli Genny, Amodeo Ilaria, Gulden Silvia, Cortesi Valeria, Manzoni Francesca, Pesenti Nicola, Tripodi Matteo, Pravatà Valentina, Lonati Caterina, Cervellini Gaia, Mosca Fabio, Cavallaro Giacomo

机构信息

Neonatal Intensive Care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.

Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy.

出版信息

Biomedicines. 2022 May 20;10(5):1185. doi: 10.3390/biomedicines10051185.

DOI:10.3390/biomedicines10051185
PMID:35625922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9138391/
Abstract

Very preterm infants are exposed to prenatal inflammatory processes and early postnatal hemodynamic and respiratory complications, but limited data are available about the endothelial effect of these conditions. The present pilot study investigates the perinatal endothelial phenotype in very preterm infants (VPIs) and explores its predictive value on neonatal mortality and hemodynamic and respiratory complications. Angiopoietin 1 (Ang-1), Ang-2, E-selectin, vascular adhesion molecule 1 (VCAM-1), tissue factor (TF), and endothelin 1 (ET-1) concentrations were tested in first (T1), 3rd (T2), and 7-10th (T3) day of life in 20 VPIs using Luminex technology and compared with 14 healthy full-term infants (FTIs). Compared to FTIs, VPIs had lower Ang-1 at T1 and T2; higher Ang-2 at T1, T2, and T3; higher Ang-2/Ang-1 ratio at T1, T2, and T3; lower E-selectin at T1, T2, and T3; higher VCAM-1 at T1; higher TF at T2. No differences in concentrations were found in neonatal deaths. VPIs with hemodynamic or respiratory complications had higher Ang-2 at T3. Perinatal low Ang-1 and high Ang-2 associated with high VCAM-1 and TF in VPIs suggest a proinflammatory endothelial phenotype, resulting from the synergy of a pathological prenatal inheritance and a premature extrauterine transition.

摘要

极早产儿会经历产前炎症过程以及出生后早期的血流动力学和呼吸并发症，但关于这些情况对内皮细胞的影响，现有数据有限。本前瞻性研究调查了极早产儿（VPI）围产期的内皮细胞表型，并探讨其对新生儿死亡率以及血流动力学和呼吸并发症的预测价值。采用Luminex技术检测了20例VPI出生第1天（T1）、第3天（T2）和第7 - 10天（T3）的血管生成素1（Ang - 1）、血管生成素2（Ang - 2）、E - 选择素、血管细胞黏附分子1（VCAM - 1）、组织因子（TF）和内皮素1（ET - 1）浓度，并与14例健康足月儿（FTI）进行比较。与FTI相比，VPI在T1和T2时Ang - 1较低；在T1、T2和T3时Ang - 2较高；在T1、T2和T3时Ang - 2/Ang - 1比值较高；在T1、T2和T3时E - 选择素较低；在T1时VCAM - 1较高；在T2时TF较高。新生儿死亡病例的浓度无差异。发生血流动力学或呼吸并发症的VPI在T3时Ang - 2较高。VPI围产期低Ang - 1和高Ang - 2与高VCAM - 1和TF相关，提示存在促炎性内皮细胞表型，这是病理性产前遗传和宫外过早过渡协同作用的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a395/9138391/1796c5896979/biomedicines-10-01185-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a395/9138391/43cb33aca0a2/biomedicines-10-01185-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a395/9138391/636808161443/biomedicines-10-01185-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a395/9138391/1796c5896979/biomedicines-10-01185-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a395/9138391/43cb33aca0a2/biomedicines-10-01185-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a395/9138391/636808161443/biomedicines-10-01185-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a395/9138391/1796c5896979/biomedicines-10-01185-g003.jpg

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Association of the dysfunctional placentation endotype of prematurity with bronchopulmonary dysplasia: a systematic review, meta-analysis and meta-regression.
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Thorax. 2022 Mar;77(3):268-275. doi: 10.1136/thoraxjnl-2020-216485. Epub 2021 Jul 23.
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