Pi W P
Proc Natl Sci Counc Repub China B. 1986 Oct;10(4):245-9.
The effectiveness of estradiol (E2) and progesterone (P4) in inducing the release of the luteinizing hormone (LH) in the acutely ovariectomized (OVx) rats was studied. Female rats were Ovx in different stages of the estrous cycles and received a series of injections of E2 and P4. LH dynamic changes in the blood were examined in the afternoon of the following day after Ovx. Intact rats treated with oil vehicle or E2 and P4 were used as controls. The surgical operation and oil treatment did not interfere with the normal reproductive rhythm and LH secretion, but treatment with E2 and P4 did facilitate the LH release in some intact rats. E2 and P4 were very effective in inducing LH release in Ovx rats as compared with controls. Results indicated that E2 and P4 are essential substances in eliciting the LH surge, but their efficacies are dependent on the stage in the estrous cycles.
研究了雌二醇（E2）和孕酮（P4）对急性卵巢切除（OVx）大鼠促黄体生成素（LH）释放的诱导作用。将雌性大鼠在发情周期的不同阶段进行卵巢切除，并接受一系列E2和P4注射。在卵巢切除后的次日下午检测血液中LH的动态变化。用油性载体或E2和P4处理的完整大鼠作为对照。手术操作和油性处理并未干扰正常的生殖节律和LH分泌，但用E2和P4处理确实促进了一些完整大鼠的LH释放。与对照相比，E2和P4在诱导OVx大鼠LH释放方面非常有效。结果表明，E2和P4是引发LH峰的必需物质，但其效力取决于发情周期的阶段。
