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降糖治疗对2型糖尿病患者急性冠脉综合征预后的影响

The Impact of Hypoglycemic Therapy on the Prognosis for Acute Coronary Syndrome in Patients with Type 2 Diabetes.

作者信息

Nikolaev K Yu, Shevela A I, Mustafina S V, Rymar O D, Ovsyannikova A K, Zelenskaya E M, Kovaleva A Y, Lifshits G I

机构信息

Institute of Internal and Preventive Medicine-Branch of Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 175/1 Borisa Bogatkova Str., Novosibirsk 630089, Russia.

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 8 Ak. Lavrentiev, Novosibirsk 630090, Russia.

出版信息

J Pers Med. 2022 May 22;12(5):845. doi: 10.3390/jpm12050845.

DOI:10.3390/jpm12050845
PMID:35629267
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9143707/
Abstract

The article discusses particular circumstances of acute coronary syndrome (ACS) in patients with type 2 diabetes (T2D). In addition, the available literature data and clinical guidelines reflecting the role of hypoglycemic therapy as a cardioprotection factor in ACS are analyzed. The article considers possible protective molecular mechanisms of various groups of drugs in ischemic cardiomyocytes.

摘要

本文讨论了2型糖尿病（T2D）患者急性冠状动脉综合征（ACS）的特殊情况。此外，还分析了反映降糖治疗作为ACS心脏保护因素作用的现有文献数据和临床指南。本文探讨了各类药物在缺血心肌细胞中的可能保护分子机制。

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J Pers Med. 2022 May 22;12(5):845. doi: 10.3390/jpm12050845.
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本文引用的文献

1
Vildagliptin vs. insulin treatment alone in diabetic acute coronary syndrome patients.维格列汀对比单独胰岛素治疗在糖尿病合并急性冠脉综合征患者中的疗效。
Coron Artery Dis. 2021 Jan;32(1):4-9. doi: 10.1097/MCA.0000000000000901.
2
Recurrent cardiovascular events in patients with newly diagnosed acute coronary syndrome: Influence of diabetes and its management with medication.新发急性冠脉综合征患者的心血管再发事件：糖尿病的影响及其药物治疗管理。
J Diabetes Complications. 2020 Mar;34(3):107511. doi: 10.1016/j.jdiacomp.2019.107511. Epub 2019 Dec 16.
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2. Classification and Diagnosis of Diabetes: .2. 糖尿病的分类和诊断： 。
Diabetes Care. 2020 Jan;43(Suppl 1):S14-S31. doi: 10.2337/dc20-S002.
4
Prognostic value of HbA1c for in-hospital and short-term mortality in patients with acute coronary syndrome: a systematic review and meta-analysis.糖化血红蛋白对急性冠状动脉综合征患者住院期间和短期死亡率的预后价值：系统评价和荟萃分析。
Cardiovasc Diabetol. 2019 Dec 11;18(1):169. doi: 10.1186/s12933-019-0970-6.
5
GLP 1 receptor agonists, glycemic variability, oxidative stress and acute coronary syndrome.GLP-1 受体激动剂、血糖变异性、氧化应激与急性冠脉综合征。
Med Hypotheses. 2020 Mar;136:109504. doi: 10.1016/j.mehy.2019.109504. Epub 2019 Nov 18.
6
Effects of Dapagliflozin on Symptoms, Function, and Quality of Life in Patients With Heart Failure and Reduced Ejection Fraction: Results From the DAPA-HF Trial.达格列净对射血分数降低的心力衰竭患者症状、功能和生活质量的影响：来自 DAPA-HF 试验的结果。
Circulation. 2020 Jan 14;141(2):90-99. doi: 10.1161/CIRCULATIONAHA.119.044138. Epub 2019 Nov 17.
7
Implementing simple algorithms to improve glucose and lipid management in people with diabetes and acute coronary syndrome.实施简单算法以改善糖尿病合并急性冠状动脉综合征患者的血糖和血脂管理。
Diabet Med. 2019 Dec;36(12):1643-1651. doi: 10.1111/dme.14095. Epub 2019 Aug 9.
8
The Dapagliflozin And Prevention of Adverse-outcomes in Heart Failure (DAPA-HF) trial: baseline characteristics.达格列净和心力衰竭结局预防（DAPA-HF）试验：基线特征。
Eur J Heart Fail. 2019 Nov;21(11):1402-1411. doi: 10.1002/ejhf.1548. Epub 2019 Jul 15.
9
Glucose-lowering therapy and cardiovascular outcomes in patients with type 2 diabetes mellitus and acute coronary syndrome.降糖治疗与 2 型糖尿病合并急性冠脉综合征患者的心血管结局。
Diab Vasc Dis Res. 2019 Sep;16(5):399-414. doi: 10.1177/1479164119845612. Epub 2019 May 2.
10
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Cardiovasc Diabetol. 2019 Apr 23;18(1):52. doi: 10.1186/s12933-019-0858-5.